A Case Series of Refractory Pediatric Atopic Dermatitis Effectively Treated With Dupilumab in Combination With Abrocitinib.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-03 DOI:10.1111/pde.15761

Wei Chern Gavin Fong, Htet Hla Win Kaung, Rhea Lopes, Alpa Kanji, Jane Ravenscroft, Ting Seng Tang, Carsten Flohr

引用次数: 0

Abstract

Children with severe atopic dermatitis (AD), refractory to conventional systemic treatment as well as single-agent biologic and Janus kinase inhibitor (JAKi) such as abrocitinib, currently face a lack of treatment options. In response to this clinical conundrum, we present three cases of severe and refractory pediatric AD successfully managed with combined dupilumab and abrocitinib. These children had exhausted all conventional treatments and had undergone treatment with both dupilumab and abrocitinib individually, as well as dupilumab in conjunction with methotrexate. It was only when the combination of dupilumab and abrocitinib was introduced that they finally achieved noticeable and sustained improvements in disease control.

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杜匹单抗联合阿罗西替尼有效治疗难治性儿童特应性皮炎的病例系列。

重症特应性皮炎（AD）患儿对传统的全身治疗以及单药生物制剂和Janus激酶抑制剂（JAKi）（如阿昔替尼）难治，目前缺乏治疗选择。针对这一临床难题，我们介绍了三例联合使用杜比单抗和阿罗西替尼成功治疗的严重难治性儿科 AD 病例。这些患儿已经用尽了所有常规治疗方法，既接受过杜比鲁单抗和阿罗西替尼的单独治疗，也接受过杜比鲁单抗与甲氨蝶呤的联合治疗。只有当杜比鲁单抗和阿罗西替尼联合使用时，他们的疾病控制情况才最终得到了明显而持续的改善。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.