Homocysteine Blood Levels and Mandatory Folic Acid Fortification in Serbia.

IF 2.6 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current pharmaceutical design Pub Date : 2024-10-03 DOI:10.2174/0113816128326875240916050251

Zorana Vasiljevic, Natasa Zlatic, Dubravka Rajic, Predrag Mitrovic, Mihajlo Viduljevic, Dragan Matic, Milika Asanin, Sanja Stankovic

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引用次数: 0

Abstract

Introduction/objective: The current study aims to investigate the blood Hcy levels in patients with CAD and hypertension in Serbia, a country with a high incidence and mortality of both diseases.

Methods: The level of Hcy in the Serbian population was assessed in 123 patients with chronic coronary artery disease (CAD) and hypertension. There were 53 patients with chronic CAD and 70 patients with hypertension (HTA), but without CAD.

Results: The Hcy levels were high in both groups of patients (the mean Hcy level of 16.0 ± 7.0 μmol/L) without a statistical difference between the patients in the CAD (14.9 ± 7.3 μmol/L) and hypertension (16.7 ± 6.7 μmol/L) groups. Hypercholesterolemia was found in 81% of the patients with CAD and 92.0% of the patients with HTA, as a common concern across both clinical conditions. It was also found that not a single conventional risk factor (diabetes, hypertension, the smoking status, the family history of CAD, and hyperlipidemia) may individually influence Hcy levels. By contrast, the low levels of vitamin B12 may be related to the high levels of Hcy.

Conclusion: Given the fact that it is known that various factors interact and influence Hcy levels and associated cardiovascular risks, specific dietary habits, lifestyle and the other Serbia-specific possible factors were done.

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塞尔维亚的同型半胱氨酸血药浓度和强制性叶酸强化剂。

引言/目的：塞尔维亚是这两种疾病的高发病率和高死亡率国家：对 123 名慢性冠状动脉疾病（CAD）和高血压患者的 Hcy 水平进行了评估。其中，53 名患者患有慢性冠状动脉疾病，70 名患者患有高血压 (HTA)，但没有冠状动脉疾病：两组患者的 Hcy 水平都很高（平均 Hcy 水平为 16.0 ± 7.0 μmol/L），但 CAD 组（14.9 ± 7.3 μmol/L）和高血压组（16.7 ± 6.7 μmol/L）患者的 Hcy 水平没有统计学差异。81%的 CAD 患者和 92.0% 的 HTA 患者患有高胆固醇血症，这是两种临床症状的共同关注点。研究还发现，没有一个常规风险因素（糖尿病、高血压、吸烟状况、CAD 家族史和高脂血症）会单独影响 Hcy 水平。相比之下，维生素 B12 含量低可能与 Hcy 含量高有关：众所周知，各种因素相互作用，影响 Hcy 水平和相关的心血管风险，因此我们对特定的饮食习惯、生活方式和其他塞尔维亚特有的可能因素进行了研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current pharmaceutical design 医学-药学

CiteScore

6.30

自引率

0.00%

发文量

302

审稿时长

2 months

期刊介绍： Current Pharmaceutical Design publishes timely in-depth reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field. Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.