Research progress on the nano-delivery systems of food-derived bioactive components

IF 4.8 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Food Bioscience Pub Date : 2024-09-26 DOI:10.1016/j.fbio.2024.105189

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Abstract

Food-derived bioactive components (BC) are celebrated for their health-enhancing properties, but their application was limited in terms of the low solubility, weak stability, and poor bioavailability. To overcome these challenges, various nano-delivery systems have been developed and extensively investigated. This review focused on the most prominent nano-delivery systems, such as nanoparticles have emerged as versatile carriers, allowing for improved solubility and controlled release of BC. Nano-emulsions offer enhanced bioavailability and stability, particularly for lipophilic BC. Liposomes, with their cell-membrane-like structure, facilitate efficient intracellular delivery. Solid lipid nanoparticles and nanostructured lipid carriers provide options for controlled release and protection against environmental factors. Additionally, various novel nano-delivery systems have been designed to cater to specific ingredient and application requirements. This review highlighted their advantages, challenges, and recent breakthroughs. The intricate interplay between nano-carrier properties and BC characteristics was elucidated, offering valuable insights for the development of functional foods with enhanced health benefits.

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食品生物活性成分纳米输送系统的研究进展

从食物中提取的生物活性成分（BC）因其增进健康的特性而备受赞誉，但其应用却因溶解度低、稳定性差和生物利用率低而受到限制。为了克服这些挑战，人们开发并广泛研究了各种纳米给药系统。本综述侧重于最突出的纳米给药系统，如纳米颗粒已成为多功能载体，可改善 BC 的溶解度和控释。纳米乳剂可提高生物利用度和稳定性，特别是对于亲脂性生物碱。脂质体具有类似细胞膜的结构，可促进高效的细胞内给药。固体脂质纳米颗粒和纳米结构脂质载体为控制释放和抵御环境因素提供了选择。此外，还设计了各种新型纳米给药系统，以满足特定成分和应用的要求。本综述重点介绍了它们的优势、挑战和最新突破。该综述阐明了纳米载体特性与 BC 特性之间错综复杂的相互作用，为开发具有更多健康益处的功能食品提供了宝贵的见解。

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来源期刊

Food Bioscience Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

6.40

自引率

5.80%

发文量

671

审稿时长

27 days

期刊介绍： Food Bioscience is a peer-reviewed journal that aims to provide a forum for recent developments in the field of bio-related food research. The journal focuses on both fundamental and applied research worldwide, with special attention to ethnic and cultural aspects of food bioresearch.