Docosahexaenoic acid supplementation and infant brain development: role of gut microbiome

IF 3.4 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research Pub Date : 2024-09-07 DOI:10.1016/j.nutres.2024.08.005

Xi Fang , Soon Lee , Srujana Rayalam , Hea Jin Park

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引用次数: 0

Abstract

Perinatal stage represents a critical period for brain development. Docosahexaenoic acid (DHA) is a ω-3 polyunsaturated fatty acid preferentially accumulated in the brain that may benefit neurodevelopment. Microbial colonization and maturation parallel with the rapid development of infant metabolic and brain function that may influence the effects of DHA on neurological development. This review aims to summarize the current literature on the mediating effects of DHA on brain and gut microbiome development and attempts to reevaluate the efficacy of DHA from a gut microbiome–mediated perspective. Specifically, the regulatory roles of DHA on hypothalamic-pituitary-adrenal axis, inflammation, and neuroactive mediators may be partly moderated through gut microbiome. Consideration of the gut microbiome and gut–brain communication, when evaluating the efficacy of DHA, may provide new insights in better understanding the mechanisms of DHA and impart advantages to future development of nutritional therapy based on the nutrient-microbiome interaction.

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补充二十二碳六烯酸与婴儿大脑发育：肠道微生物群的作用。

围产期是大脑发育的关键时期。二十二碳六烯酸（DHA）是一种ω-3 多不饱和脂肪酸，优先在大脑中积累，可能有益于神经发育。微生物的定植和成熟与婴儿新陈代谢和大脑功能的快速发展并行，这可能会影响 DHA 对神经系统发育的影响。本综述旨在总结目前有关 DHA 对大脑和肠道微生物组发育的介导作用的文献，并尝试从肠道微生物组介导的角度重新评估 DHA 的功效。具体来说，DHA 对下丘脑-垂体-肾上腺轴、炎症和神经活性介质的调节作用可能部分通过肠道微生物组来调节。在评估 DHA 的疗效时考虑肠道微生物组和肠道与大脑的交流，可能会为更好地理解 DHA 的作用机制提供新的见解，并为未来开发基于营养素-微生物组相互作用的营养疗法带来优势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition Research 医学-营养学

CiteScore

7.60

自引率

2.20%

发文量

107

审稿时长

58 days

期刊介绍： Nutrition Research publishes original research articles, communications, and reviews on basic and applied nutrition. The mission of Nutrition Research is to serve as the journal for global communication of nutrition and life sciences research on diet and health. The field of nutrition sciences includes, but is not limited to, the study of nutrients during growth, reproduction, aging, health, and disease. Articles covering basic and applied research on all aspects of nutrition sciences are encouraged, including: nutritional biochemistry and metabolism; metabolomics, nutrient gene interactions; nutrient requirements for health; nutrition and disease; digestion and absorption; nutritional anthropology; epidemiology; the influence of socioeconomic and cultural factors on nutrition of the individual and the community; the impact of nutrient intake on disease response and behavior; the consequences of nutritional deficiency on growth and development, endocrine and nervous systems, and immunity; nutrition and gut microbiota; food intolerance and allergy; nutrient drug interactions; nutrition and aging; nutrition and cancer; obesity; diabetes; and intervention programs.