Impact of ESKAPE Pathogens on Bacteremia: A Three-Year Surveillance Study at a Major Hospital in Southern Italy.

IF 4.3 2区医学 Q1 INFECTIOUS DISEASES

Antibiotics-Basel Pub Date : 2024-09-21 DOI:10.3390/antibiotics13090901

Mariagrazia De Prisco, Roberta Manente, Biagio Santella, Enrica Serretiello, Federica Dell'Annunziata, Emanuela Santoro, Francesca F Bernardi, Chiara D'Amore, Alessandro Perrella, Pasquale Pagliano, Giovanni Boccia, Gianluigi Franci, Veronica Folliero

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引用次数: 0

Abstract

Background/objectives: ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) pose a serious public health threat as they are resistant to multiple antimicrobial agents. Bloodstream infections (BSIs) caused by ESKAPE bacteria have high mortality rates due to the limited availability of effective antimicrobials. This study aimed to evaluate the prevalence and susceptibility of ESKAPE pathogens causing BSIs over three years in a large tertiary hospital in Salerno.

Methods: Conducted at the Clinical Microbiology Laboratory of San Giovanni di Dio e ''Ruggi D'Aragona'' Hospital from January 2020 to December 2022, blood culture samples from different departments were incubated in the BD BACTEC™ system for 5 days. Species identification was performed using MALDI-TOF MS, and antimicrobial resistance patterns were determined by the VITEK2 system.

Results: Out of 3197 species isolated from positive blood cultures, 38.7% were ESKAPE bacteria. Of these, 59.9% were found in blood culture samples taken from men, and the most affected age group was those aged >60 years. (70.6%). Staphylococcus aureus was the main BSI pathogen (26.3%), followed by Klebsiella pneumoniae (15.8%). Significant resistance rates were found, including 35% of Staphylococcus aureus being resistant to oxacillin and over 90% of Acinetobacter baumannii being resistant to carbapenems.

Conclusions: These results highlight the urgent need for antimicrobial stewardship programs to prevent incurable infections.

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ESKAPE 病原体对菌血症的影响：意大利南部一家大型医院的三年监测研究。

背景/目标：ESKAPE 病原体（粪肠球菌、金黄色葡萄球菌、肺炎克雷伯氏菌、鲍曼不动杆菌、铜绿假单胞菌和肠杆菌属）对多种抗菌剂具有耐药性，因此对公共卫生构成严重威胁。由于有效抗菌药物有限，ESKAPE 细菌引起的血流感染（BSI）死亡率很高。本研究旨在评估萨莱诺一家大型三级医院三年来由 ESKAPE 病原体引起 BSI 的流行率和敏感性：2020年1月至2022年12月，在San Giovanni di Dio e 'Ruggi D'Aragona''医院的临床微生物实验室进行了一项研究，来自不同科室的血液培养样本在BD BACTEC™系统中培养5天。使用 MALDI-TOF MS 进行菌种鉴定，并使用 VITEK2 系统确定抗菌药耐药性模式：结果：从阳性血液培养物中分离出的 3197 个菌种中，38.7% 为 ESKAPE 细菌。其中，59.9%在男性血液培养样本中发现，受影响最大的年龄组是年龄大于 60 岁的人群（70.6%）。(70.6%).金黄色葡萄球菌是 BSI 的主要病原体（26.3%），其次是肺炎克雷伯菌（15.8%）。耐药率很高，包括 35% 的金黄色葡萄球菌对奥沙西林耐药，超过 90% 的鲍曼不动杆菌对碳青霉烯类耐药：这些结果突出表明，迫切需要抗菌药物管理计划来预防无法治愈的感染。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Antibiotics-Basel Pharmacology, Toxicology and Pharmaceutics-General Pharmacology, Toxicology and Pharmaceutics

CiteScore

7.30

自引率

14.60%

发文量

1547

审稿时长

11 weeks

期刊介绍： Antibiotics (ISSN 2079-6382) is an open access, peer reviewed journal on all aspects of antibiotics. Antibiotics is a multi-disciplinary journal encompassing the general fields of biochemistry, chemistry, genetics, microbiology and pharmacology. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the length of papers.