Exploring Hepatocellular Carcinoma Pathogenesis: The Influence of Genetic Polymorphisms.

IF 2.6 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current pharmaceutical design Pub Date : 2024-09-18 DOI:10.2174/0113816128327773240827062719

Samaneh Mollazadeh, Nikoo Saeedi, Abdulridha Mohammed Al-Asady, Elnaz Ghorbani, Majid Khazaei, Mikhail Ryzhikov, Amir Avan, Seyed Mahdi Hasanian

引用次数: 0

Abstract

Hepatocellular carcinoma (HCC) is influenced by several factors, among which genetic polymorphisms play a key role. Polymorphisms in various genes affect key pathways involved in HCC development, including metabolism, expression of inflammatory cytokines, cell proliferation, and apoptosis regulation. These polymorphisms induce differential effects on susceptibility to HCC, disease progression, and treatment outcomes. Understanding the effect of genetic variations on HCC pathogenesis is essential to elucidate underlying mechanisms and identify potential therapeutic targets. This review explores the diverse roles of genetic polymorphisms in HCC, providing insights into the complex interplay between genetic factors and disease development.

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探索肝细胞癌的发病机制：基因多态性的影响。

肝细胞癌（HCC）受多种因素影响，其中基因多态性起着关键作用。各种基因的多态性会影响参与 HCC 发展的关键通路，包括代谢、炎症细胞因子的表达、细胞增殖和凋亡调节。这些多态性会对 HCC 易感性、疾病进展和治疗效果产生不同的影响。了解基因变异对 HCC 发病机制的影响对于阐明潜在机制和确定潜在治疗靶点至关重要。本综述探讨了遗传多态性在 HCC 中的不同作用，为了解遗传因素与疾病发展之间复杂的相互作用提供了见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current pharmaceutical design 医学-药学

CiteScore

6.30

自引率

0.00%

发文量

302

审稿时长

2 months

期刊介绍： Current Pharmaceutical Design publishes timely in-depth reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field. Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.