Senoinflammation as the underlying mechanism of aging and its modulation by calorie restriction

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2024-09-14 DOI:10.1016/j.arr.2024.102503

Sang Gyun Noh , Hyun Woo Kim , Seungwoo Kim , Ki Wung Chung , Young-Suk Jung , Jeong-Hyun Yoon , Byung Pal Yu , Jaewon Lee , Hae Young Chung

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引用次数: 0

Abstract

Senoinflammation is characterized by an unresolved low-grade inflammatory process that affects multiple organs and systemic functions. This review begins with a brief overview of the fundamental concepts and frameworks of senoinflammation. It is widely involved in the aging of various organs and ultimately leads to progressive systemic degeneration. Senoinflammation underlying age-related inflammation, is causally related to metabolic dysregulation and the formation of senescence-associated secretory phenotype (SASP) during aging and age-related diseases. This review discusses the biochemical evidence and molecular biology data supporting the concept of senoinflammation and its regulatory processes, highlighting the anti-aging and anti-inflammatory effects of calorie restriction (CR). Experimental data from CR studies demonstrated effective suppression of various pro-inflammatory cytokines and chemokines, lipid accumulation, and SASP during aging. In conclusion, senoinflammation represents the basic mechanism that creates a microenvironment conducive to aging and age-related diseases. Furthermore, it serves as a potential therapeutic target for mitigating aging and age-related diseases.

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作为衰老根本机制的老年性炎症及其对卡路里限制的调节作用

衰老性炎症的特点是一种影响多个器官和系统功能的未解决的低级炎症过程。本综述首先简要概述了衰老性炎症的基本概念和框架。衰老炎广泛参与各种器官的衰老，并最终导致进行性系统退化。衰老相关炎症背后的衰老炎症与衰老和老年相关疾病过程中的代谢失调和衰老相关分泌表型（SASP）的形成有因果关系。本综述讨论了支持衰老炎症概念及其调控过程的生化证据和分子生物学数据，强调了卡路里限制（CR）的抗衰老和抗炎症作用。卡路里限制研究的实验数据表明，在衰老过程中，各种促炎症细胞因子和趋化因子、脂质积累和 SASP 均受到有效抑制。总之，衰老性炎症是形成有利于衰老和老年相关疾病的微环境的基本机制。此外，它还是缓解衰老和老年相关疾病的潜在治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.