Natural and Bioinspired Lipidic Alkynylcarbinols as Leishmanicidal, Antiplasmodial, Trypanocidal, Fungicidal, Antibacterial, and Antimycobacterial Agents
IF 3.3
2区 生物学
Q2 CHEMISTRY, MEDICINAL
引用次数: 0
Abstract
The present review article recapitulates for the first time the antipathogenic biological data of a series of lipidic natural products and synthetic analogues thereof characterized by the presence in their structure of an alkynylcarbinol unit. The cytotoxic properties of such natural and bioinspired compounds have been covered by several literature overviews, but to date, no review article detailing their activity against pathogens has been proposed. This article thus aims at providing a comprehensive overview of the field including early studies from the 1970s and 1980s with a specific focus on results published from the late 1990s until nowadays. Publications presenting the data of almost 50 different natural products are reported. Detailed activities encompass the fields of leishmanicidal, antiplasmodial, trypanocidal, fungicidal, and mainly antibacterial and antimycobacterial compounds. The few published studies aimed at exploring the structure–activity relationship in these series are also described. Around 15 different synthetic analogues of natural products, selected among the most active reported, are also presented. The rare data available regarding the antipathogenic mode of action of these products are recalled, and finally, a comparative analysis of the available biological data is proposed with the aim of identifying the key structural determinants for the bioactivity against pathogens of these unusual compounds.
作为利什曼杀菌剂、抗原虫剂、杀锥虫剂、杀真菌剂、抗菌剂和抗霉菌剂的天然和生物脂类炔基碳水化合物
本综述文章首次概述了一系列脂质天然产物及其合成类似物的抗病原生物数据，这些天然产物和合成类似物的特点是其结构中存在一个炔基香芹醇单元。此类天然化合物和生物启发化合物的细胞毒性特性已被多篇文献综述所涵盖，但迄今为止，还没有一篇综述文章详细介绍它们对病原体的活性。因此，本文旨在对这一领域进行全面概述，包括 20 世纪 70 年代和 80 年代的早期研究，并特别关注 20 世纪 90 年代末至今发表的研究成果。文章报告了近 50 种不同天然产品的数据。详细的活性包括杀利什曼病、抗疟、杀锥虫、杀真菌，主要是抗菌和抗霉菌化合物。此外，还介绍了为数不多的旨在探索这些系列化合物结构与活性关系的已发表研究成果。此外，还介绍了约 15 种天然产品的合成类似物，这些类似物都是从已报道的最具活性的天然产品中挑选出来的。回顾了有关这些产品抗病原作用模式的罕见数据，最后提出了对现有生物数据进行比较分析的建议，目的是找出这些不同寻常的化合物对病原体具有生物活性的关键结构决定因素。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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来源期刊
CiteScore
9.10
自引率
5.90%
发文量
294
审稿时长
2.3 months
期刊介绍：
The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
When new compounds are reported, manuscripts describing their biological activity are much preferred.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
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