Recent Advances in Phenazine Natural Products: Biosynthesis and Metabolic Engineering

IF 5.7 1区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY

Journal of Agricultural and Food Chemistry Pub Date : 2024-09-20 DOI:10.1021/acs.jafc.4c05294

Wei Huang, Yupeng Wan, Huai Su, Zhe Zhang, Yingjie Liu, Mohd Sadeeq, Mo Xian, Xinjun Feng, Peng Xiong, Feifei Hou

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Abstract

Phenazine natural products are a class of nitrogen-containing heterocyclic compounds produced by microorganisms. The tricyclic ring molecules show various chemical structures and extensive pharmacological activities, such as antimicrobial, anticancer, antiparasitic, anti-inflammatory, and insecticidal activities, with low toxicity to the environment. Since phenazine-1-carboxylic acid has been developed as a registered biopesticide, the application of phenazine natural products will be promising in the field of agriculture pathogenic fungi control based on broad-spectrum antifungal activity, minimal toxicity to the environment, and improvement of crop production. Currently, there are still plenty of intriguing hidden biosynthetic pathways of phenazine natural products to be discovered, and the titer of naturally occurring phenazine natural products is insufficient for agricultural applications. In this review, we spotlight the progress regarding biosynthesis and metabolic engineering research of phenazine natural products in the past decade. The review provides useful insights concerning phenazine natural products production and more clues on new phenazine derivatives biosynthesis.

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吩嗪类天然产品的最新进展：生物合成与代谢工程

吩嗪类天然产物是微生物产生的一类含氮杂环化合物。三环分子具有多种化学结构和广泛的药理活性，如抗菌、抗癌、抗寄生虫、消炎和杀虫等，对环境的毒性较低。由于酚嗪-1-羧酸已被开发为注册生物农药，酚嗪类天然产物具有广谱抗真菌活性、对环境毒性小、提高作物产量等特点，在农业病原真菌防治领域的应用将大有可为。目前，酚嗪类天然产物仍有许多耐人寻味的隐蔽生物合成途径有待发现，天然存在的酚嗪类天然产物在农业应用方面的滴度还不够。在这篇综述中，我们重点介绍了过去十年中吩嗪类天然产物的生物合成和代谢工程研究进展。该综述为吩嗪天然产物的生产提供了有益的启示，并为新的吩嗪衍生物的生物合成提供了更多线索。

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来源期刊

Journal of Agricultural and Food Chemistry 农林科学-农业综合

CiteScore

9.90

自引率

8.20%

发文量

1375

审稿时长

2.3 months

期刊介绍： The Journal of Agricultural and Food Chemistry publishes high-quality, cutting edge original research representing complete studies and research advances dealing with the chemistry and biochemistry of agriculture and food. The Journal also encourages papers with chemistry and/or biochemistry as a major component combined with biological/sensory/nutritional/toxicological evaluation related to agriculture and/or food.