Protective effects of Weizmannia coagulans LBK against acute cadmium toxicity in mice

IF 4.8 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY
Yibo Lu , Jie Shen , Baojie Li , Panpan Zhao , Baokun Li , Zhifeng Fang , Jiancheng Wang , Guoqi Ni , Zhexin Fan
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Abstract

Cadmium (Cd) is an environmental non-biodegradable pollutant that induces toxic effects in humans. Therefore, there is a pressing need to identify new methods to relieve cadmium-induced toxic damage. In this study, Weizmannia coagulans (formerly termed Bacillus coagulans) LBK, which was isolated from silage feed, exhibited robust Cd tolerance and adsorption capabilities. In vitro experiments demonstrated that its scavenging rate for 1,1-diphenyl-2-picryl-hydrazyl radical (DPPH) and hydroxyl radicals was 40% and 39%, respectively. In vivo, LBK significantly reduced the mortality rate of cadmium-exposed mice. Moreover, LBK increased the hepatic levels of superoxide dismutase (SOD) and catalase (CAT), and histopathology examination suggested that LBK could attenuate liver damage. W. coagulans LBK significantly altered the composition of the intestinal microbiota and increased the abundance of beneficial bacteria such as Leptospirillaceae and Lactobacillus. Metabolomics analysis of cecal contents revealed that LBK regulated amino acid metabolic disorders caused by Cd exposure and restored the levels of glutamic acid, leucine, and aspartic acid. Based on the aforementioned advantages, W. coagulans LBK may be considered a promising candidate for alleviating oxidative stress caused by acute Cd exposure.

Abstract Image

地黄 LBK 对小鼠急性镉中毒的保护作用
镉(Cd)是一种不可生物降解的环境污染物,会对人体产生毒性影响。因此,迫切需要找到新的方法来缓解镉引起的毒性损伤。在这项研究中,从青贮饲料中分离出的凝结芽孢杆菌(原名凝结芽孢杆菌)LBK表现出了强大的镉耐受性和吸附能力。体外实验表明,它对 1,1-二苯基-2-苦基肼自由基(DPPH)和羟基自由基的清除率分别为 40% 和 39%。在体内,枸杞多糖能明显降低接触镉的小鼠的死亡率。此外,枸杞多糖还能提高肝脏超氧化物歧化酶(SOD)和过氧化氢酶(CAT)的水平,组织病理学检查也表明枸杞多糖能减轻肝损伤。W. coagulans LBK能显著改变肠道微生物群的组成,增加有益菌如栉螺旋体和乳酸杆菌的数量。对盲肠内容物的代谢组学分析表明,枸杞多糖能调节镉暴露引起的氨基酸代谢紊乱,恢复谷氨酸、亮氨酸和天冬氨酸的水平。基于上述优点,W. coagulans LBK 可被视为缓解急性镉暴露引起的氧化应激的一种有前途的候选物质。
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来源期刊
Food Bioscience
Food Bioscience Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
6.40
自引率
5.80%
发文量
671
审稿时长
27 days
期刊介绍: Food Bioscience is a peer-reviewed journal that aims to provide a forum for recent developments in the field of bio-related food research. The journal focuses on both fundamental and applied research worldwide, with special attention to ethnic and cultural aspects of food bioresearch.
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