{"title":"Advances in natural polysaccharides in Alzheimer's disease and Parkinson's disease: Insights from the brain-gut axis","authors":"Yueqin Feng , Fengjin Hao","doi":"10.1016/j.tifs.2024.104678","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Due to the rapid increase in aging population, there has been a rise in cases of neurodegenerative diseases (NDs), which is a major challenge for human health. Alzheimer's disease (AD) and Parkinson's disease (PD) are common degenerative disorders with complex causes and limited treatment options. The brain-gut axis is an important pathway that facilitates communication between the brain and gut. It involves intricate interactions among various systems such as nervous, immune, and endocrine systems. Recent evidence suggests a strong connection between gut microbiota and central nervous system (CNS) diseases.</p></div><div><h3>Scope and approach</h3><p>The involvement of polysaccharides in AD and PD holds promise as a potential avenue for the development of novel therapeutic strategies. This review aims to comprehensively investigate the impact of polysaccharides derived from food on NDs through the brain-gut axis, and explore the preclinical therapeutic effects of representative polysaccharides on NDs.</p></div><div><h3>Key findings and conclusions</h3><p>Our objective is to investigate the metabolic processes of polysaccharides in the gastrointestinal tract, examine their interactions with intestinal microbes, and comprehend how these processes influence the nervous system through the brain-gut axis. Furthermore, we aim to analyze the degradation process of polysaccharides in the gut, elucidate their regulatory mechanisms on microflora, provide evidence supporting their potential therapeutic applications for NDs, and emphasize clinical research data related to polysaccharides in CNS disorders. This review presents compelling evidence that gut microbiota serve as crucial regulators of naturally occurring polysaccharides while offering novel insights into utilizing various structural types of polysaccharides for addressing NDs.</p></div>","PeriodicalId":441,"journal":{"name":"Trends in Food Science & Technology","volume":"153 ","pages":"Article 104678"},"PeriodicalIF":15.1000,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Food Science & Technology","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0924224424003546","RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
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Abstract
Background
Due to the rapid increase in aging population, there has been a rise in cases of neurodegenerative diseases (NDs), which is a major challenge for human health. Alzheimer's disease (AD) and Parkinson's disease (PD) are common degenerative disorders with complex causes and limited treatment options. The brain-gut axis is an important pathway that facilitates communication between the brain and gut. It involves intricate interactions among various systems such as nervous, immune, and endocrine systems. Recent evidence suggests a strong connection between gut microbiota and central nervous system (CNS) diseases.
Scope and approach
The involvement of polysaccharides in AD and PD holds promise as a potential avenue for the development of novel therapeutic strategies. This review aims to comprehensively investigate the impact of polysaccharides derived from food on NDs through the brain-gut axis, and explore the preclinical therapeutic effects of representative polysaccharides on NDs.
Key findings and conclusions
Our objective is to investigate the metabolic processes of polysaccharides in the gastrointestinal tract, examine their interactions with intestinal microbes, and comprehend how these processes influence the nervous system through the brain-gut axis. Furthermore, we aim to analyze the degradation process of polysaccharides in the gut, elucidate their regulatory mechanisms on microflora, provide evidence supporting their potential therapeutic applications for NDs, and emphasize clinical research data related to polysaccharides in CNS disorders. This review presents compelling evidence that gut microbiota serve as crucial regulators of naturally occurring polysaccharides while offering novel insights into utilizing various structural types of polysaccharides for addressing NDs.
期刊介绍：
Trends in Food Science & Technology is a prestigious international journal that specializes in peer-reviewed articles covering the latest advancements in technology, food science, and human nutrition. It serves as a bridge between specialized primary journals and general trade magazines, providing readable and scientifically rigorous reviews and commentaries on current research developments and their potential applications in the food industry.
Unlike traditional journals, Trends in Food Science & Technology does not publish original research papers. Instead, it focuses on critical and comprehensive reviews to offer valuable insights for professionals in the field. By bringing together cutting-edge research and industry applications, this journal plays a vital role in disseminating knowledge and facilitating advancements in the food science and technology sector.
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