The Role of Population Receptive Field Sizes in Higher-Order Visual Dysfunction

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL

ACS Applied Energy Materials Pub Date : 2024-09-12 DOI:10.1007/s11910-024-01375-6

Deena Elul, Netta Levin

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Abstract

Purpose of Review

Population receptive field (pRF) modeling is an fMRI technique used to retinotopically map visual cortex, with pRF size characterizing the degree of spatial integration. In clinical populations, most pRF mapping research has focused on damage to visual system inputs. Herein, we highlight recent work using pRF modeling to study high-level visual dysfunctions.

Recent Findings

Larger pRF sizes, indicating coarser spatial processing, were observed in homonymous visual field deficits, aging, and autism spectrum disorder. Smaller pRF sizes, indicating finer processing, were observed in Alzheimer’s disease and schizophrenia. In posterior cortical atrophy, a unique pattern was found in which pRF size changes depended on eccentricity.

Summary

Changes to pRF properties were observed in clinical populations, even in high-order impairments, explaining visual behavior. These pRF changes likely stem from altered interactions between brain regions. Furthermore, some studies suggested that pRF sizes change as part of cortical reorganization, and they can point towards future prognosis.

Abstract Image

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群体感受野大小在高阶视觉功能障碍中的作用

综述目的群体感受野（pRF）建模是一种用于视网膜视图映射视觉皮层的 fMRI 技术，pRF 的大小表征了空间整合的程度。在临床人群中，大多数 pRF 映射研究都集中在视觉系统输入的损伤上。在此，我们将重点介绍利用 pRF 建模研究高级视觉功能障碍的最新研究成果。最近的研究结果在同名视野缺损、衰老和自闭症谱系障碍中观察到的 pRF 大小较大，表明空间处理较粗略。阿尔茨海默病和精神分裂症患者的 pRF 大小较小，表明空间处理较精细。在后皮质萎缩中，发现了一种独特的模式，即 pRF 大小的变化取决于偏心率。这些 pRF 变化可能源于大脑区域之间相互作用的改变。此外，一些研究表明，pRF 大小的变化是皮质重组的一部分，它们可以为未来的预后指明方向。

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.