A novel dual-gate negative capacitance TFET for highly sensitive label free biosensing

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-22 DOI:10.1088/1361-6641/ad6eb0

Ravindra Kumar Maurya, Radhe Gobinda Debnath, Ajeet Kumar Yadav, Brinda Bhowmick

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Abstract

The negative capacitance (NC) tunnel FET (NCTFET) emerges as a viable choice for the development of highly sensitive biosensors. A dual-gate (DG) structure and n+ doped pocket within the NCTFET is introduced in this study to boost biosensor performance and sensitivity. This research offers a comprehensive and comparative analysis of two biosensor designs: the DG-NCTFET and the n+ pocket-doped DG-NCTFET. Both biosensors feature nanogaps on either side of the fixed dielectric, augmenting their biomolecule capture areas. Sensitivity assessments are conducted considering charged and neutral biomolecules with a range of dielectric constants (k). The n+ pocket DG-NCTFET exhibits an I_ON sensitivity roughly 20 times greater than that of the sensor without a pocket (3.5 × 10⁶ for n+ pocket DG-NCTFET and 1.8 × 10⁵ for DG-NCTFET), primarily because it conducts current in both vertical and lateral directions. Furthermore, for fully filled nanocavity with neutral biomolecules, the maximum I_ON/I_OFF sensitivities attained are 1.2 × 10⁵ and 2.8 × 10⁴ for the n+ pocket DG-NCTFET and conventional DG-NCTFET, respectively. Moreover, this research delves into the impact of steric hindrance and the irregular placement of probes, aiming to grasp the non-ideal traits exhibited by the sensors. Significantly, sensitivity experiences a minimal increase of approximately 6%–11% when the fill factor escalates from 40% to 66%. In order to set a standard of comparison, the proposed biosensors are benchmarked against existing literature in terms of sensitivity, affirming their efficacy. The findings indicate that the proposed biosensors represent a promising alternative for detecting a wide range of both charged and neutral biomolecules.

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用于高灵敏无标记生物传感的新型双栅负电容 TFET

负电容（NC）隧道场效应晶体管（NCTFET）是开发高灵敏度生物传感器的可行选择。本研究在 NCTFET 中引入了双栅 (DG) 结构和 n+ 掺杂袋，以提高生物传感器的性能和灵敏度。本研究对两种生物传感器设计进行了全面的比较分析：DG-NCTFET 和掺杂 n+ 口袋的 DG-NCTFET。这两种生物传感器都在固定电介质的两侧设置了纳米间隙，从而扩大了生物分子捕获区域。灵敏度评估考虑了介电常数（k）范围内的带电和中性生物分子。n+ 袋 DG-NCTFET 的离子灵敏度大约是无袋传感器的 20 倍（n+ 袋 DG-NCTFET 为 3.5 × 106，DG-NCTFET 为 1.8 × 105），这主要是因为它能在垂直和横向两个方向上传导电流。此外，对于完全填充了中性生物分子的纳米腔体，n+ 袋 DG-NCTFET 和传统 DG-NCTFET 所达到的最大 ION/IOFF 灵敏度分别为 1.2 × 105 和 2.8 × 104。此外，这项研究还深入探讨了立体阻碍和探针不规则放置的影响，旨在掌握传感器表现出的非理想特性。值得注意的是，当填充因子从 40% 提升到 66% 时，灵敏度会有大约 6%-11% 的微弱增长。为了设定一个比较标准，根据灵敏度方面的现有文献，对拟议的生物传感器进行了基准测试，以肯定其功效。研究结果表明，所提出的生物传感器是检测各种带电和中性生物分子的理想选择。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.