Ketogenic diet improves fertility in patients with polycystic ovary syndrome: a brief report

IF 4 2区农林科学 Q2 NUTRITION & DIETETICS

Frontiers in Nutrition Pub Date : 2024-09-12 DOI:10.3389/fnut.2024.1395977

Yumiko Tsushima, Noura Nachawi, Kevin M. Pantalone, Marcio L. Griebeler, Ula Abed Alwahab

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Abstract

IntroductionPolycystic ovary syndrome (PCOS) affects up to 20 % of reproductive-age individuals and is strongly linked to obesity. The impacts of ketogenic diet on fertility in people with PCOS are unknown. This study aims to determine the effect of a ketogenic diet on restoration of regular menstrual cycles and fertility.MethodsAfter approval from the Institutional Review Boards of Cleveland Clinic, a retrospective analysis was conducted using the electronic health record system. We analyzed data from thirty patients (n = 30) with polycystic ovary syndrome who followed a ketogenic diet for at least 3 months at the Cleveland Clinic, Cleveland, Ohio, USA. Main outcomes were percentage of women with restoration of regular menstrual cycles and pregnancy rate.ResultsAll women (n = 30) had restoration of regular menstrual cycles. The overall pregnancy rate of women desiring pregnancy (n = 18) was 55.6% (n = 10). Pregnancy rate was 38.5% for women on metformin and 100% for those who were not (P = 0.036). Pregnancy rate was 62.5% for women using ovulation induction agents and 50.0% for those who did not (P = 0.66). Percent weight change between the pregnant and non-pregnant groups did not significantly differ [−8.1 ± 6.2, vs −6.4 ± 8.4, P = 0.64, respectively].ConclusionThis study reports a higher rate of pregnancy with the ketogenic diet in women with PCOS compared to existing literature.

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生酮饮食可提高多囊卵巢综合征患者的生育能力：简要报告

导言：多囊卵巢综合征（PCOS）影响着多达 20% 的育龄人群，并与肥胖密切相关。生酮饮食对多囊卵巢综合征患者生育能力的影响尚不清楚。本研究旨在确定生酮饮食对恢复正常月经周期和生育能力的影响。方法在获得克利夫兰诊所机构审查委员会的批准后，我们使用电子健康记录系统进行了一项回顾性分析。我们分析了来自美国俄亥俄州克利夫兰市克利夫兰诊所的 30 名多囊卵巢综合征患者（n = 30）的数据，这些患者至少坚持了 3 个月的生酮饮食。主要结果是恢复正常月经周期的妇女比例和怀孕率。希望怀孕的妇女（18 人）的总怀孕率为 55.6%（10 人）。服用二甲双胍的女性怀孕率为 38.5%，而未服用二甲双胍的女性怀孕率为 100%（P = 0.036）。使用促排卵药物的女性怀孕率为 62.5%，未使用促排卵药物的女性怀孕率为 50.0%（P = 0.66）。怀孕组和未怀孕组的体重变化百分比没有显著差异[分别为-8.1 ± 6.2，vs -6.4 ± 8.4，P = 0.64]。

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来源期刊

Frontiers in Nutrition Agricultural and Biological Sciences-Food Science

CiteScore

5.20

自引率

8.00%

发文量

2891

审稿时长

12 weeks

期刊介绍： No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health. Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.

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