Glochidion Species: A Review on Phytochemistry and Pharmacology

IF 1.5 4区 医学 Q4 CHEMISTRY, MEDICINAL
Nguyen Ngoc Linh, Nguyen Quang Hop, Phi Thi Tuyet Nhung, Pham Thi Bich Dao, Vu Quoc Manh, Ty Viet Pham, Ninh The Son
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Abstract

ObjectivesThe genus Glochidion (the family Phyllanthaceae) is used for various medicinal purposes, such as dysentery, diarrhea, cough, and skin protection. A review of phytochemical and pharmacological aspects for this remains unavailable. The current study tends to sum up a detailed list of phytochemicals, and their role in biological examinations.MethodsReferences in English were obtained by an extensive search across various electronic data sources, encompassing Web of Science, PubMed, Google Scholar, and Science Direct. The “Sci-Finder” was also utilized to find references and revise chemical structures. Referenced documents have been gathered from the 1960s to date. It also noted that Glochidion, phytochemistry, and pharmacology are likely the keywords to seek for references.ResultsOver 240 naturally occurring phytochemicals were isolated and identified from various Glochidion tissues, including terpenoids, sterols, saponins, lignans, flavonoids, mono-phenols, megastigmanes, butenolides, glycosides, alkaloids, cyanogens, tocopherols, fatty acids, and others. Three naturally occurring triterpenoids glochidonol, glochidiol, and glochidone are the likely characteristic metabolites, being isolated frequently. Glochidion crude extracts and their isolated compounds have been demonstrated as potential agents in various pharmacological targets, such as cytotoxicity, antioxidant, antiinflammation, and neuron and liver protection.ConclusionSeveral isolates acted as promising agents in pharmacological assays. The anticancer mechanisms of various triterpenoids and saponins, especially new and potential compounds, are expected. Pharmacological advancements to enhance the efficacies of Glochidion constituents, such as synergistic combinations and nano-drug formulations, are encouraged.
Glochidion Species:植物化学和药理学综述
目的Glochidion属(Phyllanthaceae)被用于多种药用目的,如痢疾、腹泻、咳嗽和皮肤保护。有关其植物化学和药理方面的综述仍然缺乏。本研究旨在总结植物化学物质的详细清单及其在生物检查中的作用。方法通过广泛搜索各种电子数据源,包括 Web of Science、PubMed、Google Scholar 和 Science Direct,获得英文参考文献。此外,还利用 "Sci-Finder "查找参考文献并修改化学结构。从 20 世纪 60 年代至今,我们一直在收集参考文献。结果从 Glochidion 的各种组织中分离并鉴定出 240 多种天然植物化学物质,包括萜类、甾醇类、皂苷类、木脂素类、黄酮类、单酚类、巨石榴烯类、丁烯内酯类、苷类、生物碱类、氰基类、生育酚类、脂肪酸类等。三种天然三萜类化合物钩吻醇、钩吻二醇和钩吻酮是可能的特征代谢物,经常被分离出来。钩吻粗萃取物及其分离出的化合物已被证明具有多种药理作用,如细胞毒性、抗氧化、抗炎、神经元和肝脏保护等。各种三萜类化合物和皂苷的抗癌机制,尤其是新的和潜在的化合物,值得期待。鼓励通过药理研究提高 Glochidion 成分的功效,如协同组合和纳米药物制剂。
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来源期刊
Natural Product Communications
Natural Product Communications 工程技术-食品科技
CiteScore
3.10
自引率
11.10%
发文量
254
审稿时长
2.7 months
期刊介绍: Natural Product Communications is a peer reviewed, open access journal studying all aspects of natural products, including isolation, characterization, spectroscopic properties, biological activities, synthesis, structure-activity, biotransformation, biosynthesis, tissue culture and fermentation. It covers the full breadth of chemistry, biochemistry, biotechnology, pharmacology, and chemical ecology of natural products. Natural Product Communications is a peer reviewed, open access journal studying all aspects of natural products, including isolation, characterization, spectroscopic properties, biological activities, synthesis, structure-activity, biotransformation, biosynthesis, tissue culture and fermentation. It covers the full breadth of chemistry, biochemistry, biotechnology, pharmacology, and chemical ecology of natural products. Natural Product Communications is a peer reviewed, open access journal studying all aspects of natural products, including isolation, characterization, spectroscopic properties, biological activities, synthesis, structure-activity, biotransformation, biosynthesis, tissue culture and fermentation. It covers the full breadth of chemistry, biochemistry, biotechnology, pharmacology, and chemical ecology of natural products.
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