Sinensetin from citrus peel alleviates DSS-induced inflammation by regulating gut microbiota and serum metabolism in mice

IF 4.8 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY
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Abstract

Sinensetin is a polymethoxylated flavone, which is considered to be an important functional composition in citrus peels. In this study, the anti-inflammatory effect and potential mechanism of sinensetin were evaluated by multi-omics analysis in the dextran sulfate sodium (DSS)-induced colitis model. The results showed that sinensetin significantly inhibited inflammation and alleviated gut microbiota imbalance in the DSS-induced mice. Sinensetin supplementation increased the abundance of Faecalibaculum, Colidextribacter, Lachnospiraceae_NK4A136_group, norank_f_norank_Clostridia_UCG-014 and Christensenella, reduced abundance of Bacteroides, Escherichia-Shigella, Parasutterella and Clostridium_sensu_stricto_1. The metabolome of serum samples showed 117 differential metabolites were significantly altered by sinensetin supplementation in colitis mice, and 24 of these metabolites were involved in the Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathway. KEGG predictions based on both gut microbiota and serum metabolites suggested that cysteine and methionine metabolism are mainly affected by sinensetin supplementation. These results indicate that sinensetin inhibit DSS-induced colitis by modulating gut microbiota and ameliorating serum metabolism.

柑橘皮中的西奈素通过调节小鼠肠道微生物群和血清代谢来缓解 DSS 诱导的炎症
西奈素是一种多甲氧基化黄酮,被认为是柑橘皮中的一种重要功能成分。本研究通过多组学分析评估了山奈苷在葡聚糖硫酸钠(DSS)诱导的结肠炎模型中的抗炎作用和潜在机制。结果表明,窦参素能显著抑制右旋糖酐硫酸钠(DSS)诱导的小鼠的炎症反应,缓解肠道微生物群失衡。补充矢车菊素后,Faecalibaculum、Colidextribacter、Lachnospiraceae_NK4A136_group、norank_f_norank_Clostridia_UCG-014 和 Christensenella 的数量增加,Bacteroides、Escherichia-Shigella、Parasutterella 和 Clostridium_sensu_stricto_1 的数量减少。血清样本的代谢组显示,在结肠炎小鼠体内补充窦参素后,117种不同的代谢物发生了显著变化,其中24种代谢物参与了《京都基因与基因组百科全书》(KEGG)信号通路。基于肠道微生物群和血清代谢物的 KEGG 预测表明,半胱氨酸和蛋氨酸代谢主要受到补充窦参素的影响。这些结果表明,窦参素可通过调节肠道微生物群和改善血清代谢来抑制DSS诱导的结肠炎。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Food Bioscience
Food Bioscience Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
6.40
自引率
5.80%
发文量
671
审稿时长
27 days
期刊介绍: Food Bioscience is a peer-reviewed journal that aims to provide a forum for recent developments in the field of bio-related food research. The journal focuses on both fundamental and applied research worldwide, with special attention to ethnic and cultural aspects of food bioresearch.
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