Effective extraction and detection of aflatoxins in cereals using nitrogen-rich benzodiimidazole linkage magnetic covalent organic framework based solid phase extraction and HPLC-MS/MS analysis

IF 6.5 1区农林科学 Q1 CHEMISTRY, APPLIED

Food Chemistry: X Pub Date : 2024-08-31 DOI:10.1016/j.fochx.2024.101797

Dan Wei , Jianliang Li , Shuangshuang Zheng , Ming Guo , Jingjing Xu , Qiao Deng , Xu Wang

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引用次数: 0

Abstract

Cereals are frequently contaminated by aflatoxins (AFs). The objective of this study was to develop an efficient extraction materials for rapidly extracting and detecting AFs. A novel amino-functionalized benzodiimidazole linkage magnetic covalent organic framework (Fe₃O₄@BB-COF) was simply fabricated by one-step cyclization and aromatization. The Fe₃O₄@BB-COF, having multiple N-containing active sites, exhibited excellent extraction capability towards AFs due to synergistic interactions, including the π-π interactions, hydrogen bonding interactions, polar interactions, electrostatic interactions and Lewis acid-base interactions. The Fe₃O₄@BB-COF based MSPE method for detecting aflatoxins has advantages of simple operation, short extraction time (6 min), and low material consumption (2 mg). This method exhibited satisfactory linearity (0.05–20 μg/kg), and sensitivity (0.01–0.45 μg/L for the detection limits) and accuracy (76.8–97.1 % for recovery) and was successfully applied for extracting and detecting AFs in cereals.

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利用富氮苯并二咪唑连接磁性共价有机框架固相萃取和 HPLC-MS/MS 分析技术有效萃取和检测谷物中的黄曲霉毒素

谷物经常受到黄曲霉毒素（AFs）的污染。本研究旨在开发一种可快速提取和检测黄曲霉毒素的高效提取材料。通过一步环化和芳香化，一种新型氨基官能化苯并二咪唑连接磁性共价有机框架（Fe3O4@BB-COF）被简单地制造出来。Fe3O4@BB-COF具有多个含N的活性位点，由于π-π相互作用、氢键相互作用、极性相互作用、静电相互作用和路易斯酸碱相互作用等协同作用，对AFs具有优异的萃取能力。基于Fe3O4@BB-COF的MSPE法检测黄曲霉毒素具有操作简单、萃取时间短（6分钟）、材料消耗少（2毫克）等优点。该方法线性关系良好（0.05-20 μg/kg）、灵敏度高（检出限为0.01-0.45 μg/L）、准确度高（回收率为76.8%-97.1%），可用于谷物中黄曲霉毒素的提取和检测。

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来源期刊

Food Chemistry: X CHEMISTRY, APPLIED-

CiteScore

4.90

自引率

6.60%

发文量

315

审稿时长

55 days

期刊介绍： Food Chemistry: X, one of three Open Access companion journals to Food Chemistry, follows the same aims, scope, and peer-review process. It focuses on papers advancing food and biochemistry or analytical methods, prioritizing research novelty. Manuscript evaluation considers novelty, scientific rigor, field advancement, and reader interest. Excluded are studies on food molecular sciences or disease cure/prevention. Topics include food component chemistry, bioactives, processing effects, additives, contaminants, and analytical methods. The journal welcome Analytical Papers addressing food microbiology, sensory aspects, and more, emphasizing new methods with robust validation and applicability to diverse foods or regions.