The role of metal ions in stroke: Current evidence and future perspectives

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2024-09-05 DOI:10.1016/j.arr.2024.102498

Shaoshuai Wang , Mengzhe Qin , Xiaochong Fan , Chao Jiang , Qingchuan Hou , Ziyi Ye , Xinru Zhang , Yunfan Yang , Jingyu Xiao , Kevin Wallace , Yousef Rastegar-Kashkooli , Qinfeng Peng , Dongqi Jin , Junyang Wang , Menglu Wang , Ruoqi Ding , Jin Tao , Yun Tai Kim , Ujjal K. Bhawal , Junmin Wang , Jian Wang

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引用次数: 0

Abstract

Metal ions play a pivotal role in maintaining optimal brain function within the human body. Nevertheless, the accumulation of these ions can result in irregularities that lead to brain damage and dysfunction. Disruptions of metal ion homeostasis can result in various pathologies, including inflammation, redox dysregulation, and blood-brain barrier disruption. While research on metal ions has chiefly focused on neurodegenerative diseases, little attention has been given to their involvement in the onset and progression of stroke. Recent studies have identified cuproptosis and confirmed ferroptosis as significant factors in stroke pathology, underscoring the importance of metal ions in stroke pathology, including abnormal ion transport, neurotoxicity, blood-brain barrier damage, and cell death. Additionally, it provides an overview of contemporary metal ion chelators and detection techniques, which may offer novel approaches to stroke treatment.

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金属离子在中风中的作用：现有证据与未来展望。

金属离子在维持人体大脑最佳功能方面发挥着关键作用。然而，这些离子的积累会导致不正常现象，从而导致脑损伤和功能障碍。金属离子平衡的破坏会导致各种病症，包括炎症、氧化还原失调和血脑屏障（BBB）破坏。尽管对金属离子的研究主要集中在神经退行性疾病上，但很少有人关注它们与中风发病和进展的关系。最近的研究发现杯突症和铁突症是中风病理的重要因素，强调了金属离子在中风病理中的重要性，包括离子转运、神经毒性、BBB 损伤和细胞死亡。此外，该报告还概述了当代金属离子螯合剂和检测技术，这些技术可为中风治疗提供新方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.