Longitudinal study for the early detection of autism in children with very preterm birth.

IF 1.4 4区医学 Q4 CLINICAL NEUROLOGY

Brain & Development Pub Date : 2024-09-05 DOI:10.1016/j.braindev.2024.08.006

Marta Marín Soro, Laura Gisbert Gustemps, Héctor Boix Alonso, Sergi Martínez-Maldonado, Ricard Coronado Contreras

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引用次数: 0

Abstract

Introduction: Very preterm birth is an important risk factor for autism spectrum disorder (ASD). The aim of this study is the early detection of ASD risk, using a follow-up protocol, in children weighing less than 1500 g at birth or born before 32 weeks of gestation.

Methods: This is a prospective longitudinal study in which a total of 133 very premature babies were monitored to the age of 2 years with the M-CHAT autism screening test and, in the event of a positive result, the Autism Diagnostic Observation Schedule (ADOS-2).

Results: 53 cases (4 out of 10) screened positive, and the rest negative. Among the positives, the ADOS-2 was administered in 50 cases, of which 24 scored above the ASD cutoff point. The average age of detection was 25.39 months. The results suggest an estimated prevalence of ASD in the very premature population of 18.46 %.

Conclusions: The application of the follow-up protocol in the very premature population is effective for early detection of ASD.

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早期发现早产儿自闭症的纵向研究。

介绍：极早产是自闭症谱系障碍（ASD）的一个重要风险因素。本研究的目的是采用随访方案，及早发现出生时体重不足 1500 克或妊娠 32 周前出生的儿童患自闭症谱系障碍的风险：这是一项前瞻性纵向研究，共对 133 名早产儿进行了 M-CHAT 自闭症筛查测试，并在测试结果呈阳性的情况下进行了自闭症诊断观察表（ADOS-2）监测，直至其 2 岁：结果：53 例（10 例中有 4 例）筛查结果呈阳性，其余呈阴性。在阳性结果中，对 50 个病例进行了 ADOS-2 测试，其中 24 个病例的得分超过了 ASD 临界点。检出的平均年龄为 25.39 个月。结果表明，在极早产儿中，ASD 的发病率估计为 18.46%：在极早产儿中应用随访方案可有效地早期发现 ASD。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain & Development 医学-临床神经学

CiteScore

3.60

自引率

0.00%

发文量

153

审稿时长

50 days

期刊介绍： Brain and Development (ISSN 0387-7604) is the Official Journal of the Japanese Society of Child Neurology, and is aimed to promote clinical child neurology and developmental neuroscience. The journal is devoted to publishing Review Articles, Full Length Original Papers, Case Reports and Letters to the Editor in the field of Child Neurology and related sciences. Proceedings of meetings, and professional announcements will be published at the Editor''s discretion. Letters concerning articles published in Brain and Development and other relevant issues are also welcome.