Unweaving type I interferons in age-related neuroinflammation.

IF 14.6 1区医学 Q1 NEUROSCIENCES

Trends in Neurosciences Pub Date : 2024-10-01 Epub Date: 2024-09-04 DOI:10.1016/j.tins.2024.08.014

David P J Hunt, Markus J Hofer

引用次数: 0

Abstract

Neuroinflammation is a feature of both neurodegenerative disease and normal brain aging. The roles of type I interferon (IFN-I) in the aged brain are incompletely understood. A recent article by Roy et al. reveals pervasive IFN-I activity in normal mouse brain aging, and highlights the importance of microglial IFN-I signaling in neuroinflammation.

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解开 I 型干扰素在与年龄相关的神经炎症中的作用。

神经炎症是神经退行性疾病和正常脑衰老的一个特征。人们对 I 型干扰素（IFN-I）在大脑老化过程中的作用尚不完全清楚。罗伊等人最近发表的一篇文章揭示了正常小鼠大脑衰老过程中普遍存在的 IFN-I 活性，并强调了小胶质细胞 IFN-I 信号在神经炎症中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Neurosciences 医学-神经科学

CiteScore

26.50

自引率

1.30%

发文量

123

审稿时长

6-12 weeks

期刊介绍： For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.