Potential implications of natural compounds on aging and metabolic regulation

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2024-08-31 DOI:10.1016/j.arr.2024.102475

Zhuozhen Li , Lili Chen , Liangliang Qu , Wenjie Yu , Tao Liu , Fangjian Ning , Jinwang Li , Xiali Guo , Fengjie Sun , Baoguo Sun , Liping Luo

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引用次数: 0

Abstract

Aging is generally accompanied by a progressive loss of metabolic homeostasis. Targeting metabolic processes is an attractive strategy for healthy-aging. Numerous natural compounds have demonstrated strong anti-aging effects. This review summarizes recent findings on metabolic pathways involved in aging and explores the anti-aging effects of natural compounds by modulating these pathways. The potential anti-aging effects of natural extracts rich in biologically active compounds are also discussed. Regulating the metabolism of carbohydrates, proteins, lipids, and nicotinamide adenine dinucleotide is an important strategy for delaying aging. Furthermore, phenolic compounds, terpenoids, alkaloids, and nucleotide compounds have shown particularly promising effects on aging, especially with respect to metabolism regulation. Moreover, metabolomics is a valuable tool for uncovering potential targets against aging. Future research should focus on identifying novel natural compounds that regulate human metabolism and should delve deeper into the mechanisms of metabolic regulation using metabolomics methods, aiming to delay aging and extend lifespan.

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天然化合物对衰老和新陈代谢调节的潜在影响。

衰老通常伴随着代谢平衡的逐渐丧失。以新陈代谢过程为靶点是一种具有吸引力的健康抗衰老策略。许多天然化合物都具有很强的抗衰老作用。本综述总结了有关衰老代谢途径的最新研究成果，并探讨了天然化合物通过调节这些途径所产生的抗衰老作用。此外，还讨论了富含生物活性化合物的天然提取物的潜在抗衰老作用。调节碳水化合物、蛋白质、脂类和烟酰胺腺嘌呤二核苷酸的新陈代谢是延缓衰老的重要策略。此外，酚类化合物、萜类化合物、生物碱和核苷酸化合物对延缓衰老，尤其是对新陈代谢的调节作用尤为明显。此外，代谢组学是发现潜在抗衰老靶点的重要工具。未来研究的重点应是发现能调节人体新陈代谢的新型天然化合物，并利用代谢组学方法深入研究新陈代谢的调节机制，从而达到延缓衰老和延长寿命的目的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.