Epidemiology and Impact of Anti-Pneumococcal Vaccination and COVID-19 on Resistance of Streptococcus pneumoniae Causing Invasive Disease in Piedmont, Italy.

IF 4.3 2区医学 Q1 INFECTIOUS DISEASES

Antibiotics-Basel Pub Date : 2024-08-06 DOI:10.3390/antibiotics13080740

Alessandro Bondi, Emanuele Koumantakis, Antonio Curtoni, Anna Maria Barbui, Marco Peradotto, Daniela Lombardi, Roberto Casale, Silvia Alizzi, Elisa Zanotto, Lorena Charrier, Rossana Cavallo, Cristina Costa

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Abstract

Background: The international surveillance of antimicrobial resistance (AMR) reports S. pneumoniae as one of leading causes of death associated with AMR. Against invasive disease, several vaccinations are available and a reduction in AMR in S. pneumoniae has been observed. Here, we evaluated the impact of anti-pneumococcal vaccination policy and the SARS-CoV2 outbreak on AMR in S. pneumoniae causing invasive disease.

Methods: We collected all strains of S. pneumoniae causing invasive disease from 2008 in the Piedmont region (Italy). Each strain was typed in order to identify the serogroup and data about AMR were collected. The population under surveillance was classified as infants, children, adults, and the old population.

Results: We collected n = 2076 S. pneumoniae strains, with 21.9% and 40.3% being resistant to penicillin G and erythromycin, respectively. We reported an increased risk of infection with penicillin-resistant S. pneumoniae among all populations and evaluated whether the infection was caused by a serotype included in the vaccine formulation. A similar increase was observed after the SARS-CoV2 outbreak.

Conclusions: In the Piedmont region, subsequently to the introduction of anti-pneumococcal vaccination, a significant increase in the risk of penicillin G-resistant invasive pneumococcal disease among infants and old population was reported. No significant impact was found for the SARS-CoV2 outbreak.

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意大利皮埃蒙特的流行病学以及抗肺炎球菌疫苗接种和 COVID-19 对引起侵袭性疾病的肺炎链球菌耐药性的影响。

背景：抗菌药耐药性（AMR）国际监测报告显示，肺炎双球菌是与 AMR 相关的主要死因之一。针对侵袭性疾病，目前有多种疫苗可供选择，而且已观察到肺炎球菌的 AMR 有所减少。在此，我们评估了抗肺炎球菌疫苗接种政策和 SARS-CoV2 爆发对引起侵袭性疾病的肺炎双球菌 AMR 的影响：方法：我们收集了 2008 年意大利皮埃蒙特大区所有引起侵袭性疾病的肺炎双球菌菌株。我们对每株菌株进行了分型，以确定其血清群，并收集了有关 AMR 的数据。监测人群分为婴儿、儿童、成人和老年人：我们共收集到 n = 2076 株肺炎链球菌菌株，其中 21.9% 和 40.3% 的菌株对青霉素 G 和红霉素耐药。我们报告了所有人群感染耐青霉素肺炎球菌的风险增加，并评估了感染是否由疫苗配方中的血清型引起。在 SARS-CoV2 爆发后也观察到了类似的增加：结论：在皮埃蒙特地区，在引入抗肺炎球菌疫苗接种后，婴儿和老年人感染耐青霉素 G 的侵袭性肺炎球菌疾病的风险显著增加。但对 SARS-CoV2 的爆发并无明显影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Antibiotics-Basel Pharmacology, Toxicology and Pharmaceutics-General Pharmacology, Toxicology and Pharmaceutics

CiteScore

7.30

自引率

14.60%

发文量

1547

审稿时长

11 weeks

期刊介绍： Antibiotics (ISSN 2079-6382) is an open access, peer reviewed journal on all aspects of antibiotics. Antibiotics is a multi-disciplinary journal encompassing the general fields of biochemistry, chemistry, genetics, microbiology and pharmacology. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the length of papers.