Impairment of inhibitory control due to repetitive subconcussions from indirect brain impacts: Evidence from event-related potentials and resting-state EEG complexity in parachuters

IF 3.5 3区医学 Q2 NEUROSCIENCES

Brain Research Bulletin Pub Date : 2024-08-20 DOI:10.1016/j.brainresbull.2024.111053

Zhenghao Fu , Min Liu. , Shuochen Wang , Haoran Zhang , Yuanyi Sun , Yang Zhou , Xiang Li , Pingjing Ming , Jian Song , Guozheng Xu

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Abstract

The present study aims to investigate the unknown relationship between inhibitory control and repetitive subconcussion induced by the indirect brain impacts. We enrolled 28 parachuters exposed to repetitive subconcussion (SC) and 27 matched health controls (HC). Parachuters who have completed at least 70 actual parachuting (71–112 times) and at least 1500 simulated platform jumps (1500–4500 times) were included in the SC group. The SC group had a reduced accuracy rate in both the Stroop congruent and incongruent conditions. Larger N2 and N450 amplitudes were elicited in the frontal regions of the SC group, which indicate compensatory adaptations to the deficit in conflict monitoring. The reduced frontal resting-state EEG complexity in full-band (1–40 Hz) may demonstrate the frontal structural damage following the indirect brain impacts of repetitive subconcussion. Pearson correlation analysis showed that in the SC group, the frontal beta-band sample entropy values are positively correlated with the accuracy rate of the Stroop incongruent condition, suggesting the frontal beta-band sample entropy values may serve as potential electrophysiological markers of impaired inhibitory control after indirectly repetitive brain impacts. This study provides the robust evidence that repetitive subconcussion resulting from indirect brain impacts may lead to impairment of inhibitory control.

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大脑间接撞击造成的重复性次撞击导致抑制控制受损：跳伞运动员事件相关电位和静息状态脑电图复杂性提供的证据。

本研究旨在调查抑制控制与间接脑撞击诱发的重复性脑震荡之间的未知关系。我们招募了 28 名暴露于重复性脑震荡（SC）的跳伞运动员和 27 名匹配的健康对照组（HC）。SC组包括至少完成过70次实际跳伞（71-112次）和至少1500次模拟平台跳伞（1500-4500次）的跳伞员。在 Stroop 一致性和非一致性条件下，SC 组的准确率都有所下降。在 SC 组的额叶区域引起了较大的 N2 和 N450 振幅，这表明了对冲突监测缺陷的补偿性适应。全频段（1-40Hz）额叶静息态脑电图复杂性降低，这可能表明重复性脑震荡对大脑的间接影响造成了额叶结构损伤。皮尔逊相关分析表明，在SC组中，额叶β波段样本熵值与Stroop不一致条件下的正确率呈正相关，这表明额叶β波段样本熵值可能是间接重复性脑震荡后抑制控制受损的潜在电生理标记。本研究为间接重复性脑撞击导致的重复性亚脑震荡可能导致抑制控制受损提供了有力的证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Research Bulletin 医学-神经科学

CiteScore

6.90

自引率

2.60%

发文量

253

审稿时长

67 days

期刊介绍： The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.