Diego J Enríquez, Julio C Alonso, Lucas Hille, Stefan Brand, Ulrike Holzgrabe, Daniela Vergara, Guillermo Montoya, Yesid A Ramírez
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引用次数: 0
Abstract
Introduction: Cannabis sativa is a highly versatile plant with a long history of cultivation and domestication. It produces multiple compounds that exert distinct and valuable therapeutic effects by modulating diverse biological systems, including the endocannabinoid system (ECS). Access to standardized, metabolically diverse, and reproducible C. sativa chemotypes and chemovars is essential for physicians to optimize individualized patient treatment and for industries to conduct drug-discovery campaigns.
Objective: This study aimed to characterize and assess the phytochemical diversity of C. sativa chemotypes in diverse ecological regions of Colombia, South America.
Methodology: Ten cannabinoids and 23 terpenes were measured using liquid and gas chromatography, in addition to other phenotypic traits, in 156 C. sativa plants that were grown in diverse ecological regions in Colombia, a hotspot for global biodiversity.
Results: Our results reveal significant phytochemical diversity in Colombian-grown C. sativa plants, with four distinct chemotypes based on cannabinoid profile. The significant amount of usually uncommon terpenes suggests that Colombia's environments may have unique capabilities that allow the plant to express these compounds. Colombia's diverse climates offer enormous cultivation potential, making it a key player in both domestic and international medicinal and recreational C. sativa trade.
Conclusion: These findings underscore Colombia's capacity to pioneer global C. sativa production diversification, particularly in South America with new emerging markets.
简介大麻是一种用途广泛的植物，其种植和驯化历史悠久。它能产生多种化合物，通过调节不同的生物系统（包括内源性大麻素系统 (ECS)）发挥独特而有价值的治疗效果。获得标准化、代谢多样化和可重现的 C. sativa 化学型和化学变种对于医生优化患者的个体化治疗和工业界开展药物发现活动至关重要：本研究旨在描述和评估南美洲哥伦比亚不同生态区域 C. sativa 化学型的植物化学多样性：除其他表型特征外，还使用液相和气相色谱法测量了生长在全球生物多样性热点地区哥伦比亚不同生态区域的 156 株 C. sativa 植物中的 10 种大麻素和 23 种萜类化合物：结果：我们的研究结果表明，哥伦比亚种植的 C. sativa 植物具有显著的植物化学多样性，根据大麻素特征可分为四种不同的化学类型。大量通常不常见的萜类化合物表明，哥伦比亚的环境可能具有独特的能力，允许植物表达这些化合物。哥伦比亚多样的气候条件提供了巨大的种植潜力，使其成为国内外药用和娱乐大麻贸易的重要参与者：这些发现强调了哥伦比亚开拓全球茄科植物生产多样化的能力，尤其是在拥有新兴市场的南美洲。
期刊介绍：
Phytochemical Analysis is devoted to the publication of original articles concerning the development, improvement, validation and/or extension of application of analytical methodology in the plant sciences. The spectrum of coverage is broad, encompassing methods and techniques relevant to the detection (including bio-screening), extraction, separation, purification, identification and quantification of compounds in plant biochemistry, plant cellular and molecular biology, plant biotechnology, the food sciences, agriculture and horticulture. The Journal publishes papers describing significant novelty in the analysis of whole plants (including algae), plant cells, tissues and organs, plant-derived extracts and plant products (including those which have been partially or completely refined for use in the food, agrochemical, pharmaceutical and related industries). All forms of physical, chemical, biochemical, spectroscopic, radiometric, electrometric, chromatographic, metabolomic and chemometric investigations of plant products (monomeric species as well as polymeric molecules such as nucleic acids, proteins, lipids and carbohydrates) are included within the remit of the Journal. Papers dealing with novel methods relating to areas such as data handling/ data mining in plant sciences will also be welcomed.
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