Evaluation of PRAME immunohistochemistry in cutaneous vascular neoplasms reveals frequent expression in primary and post-irradiation cutaneous angiosarcomas

IF 1.6 4区医学 Q3 DERMATOLOGY

Journal of Cutaneous Pathology Pub Date : 2024-08-17 DOI:10.1111/cup.14707

Andrea Krajisnik MD, MS, Neda Rezaee MD, Eleanor R. Duncan BS, Bonnie L. Balzer MD, PhD, Wonwoo Shon DO

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Abstract

Background

Preferentially expressed antigen in melanoma (PRAME) has been extensively studied in cutaneous melanocytic tumors and has proven valuable as a diagnostic adjunct in routine dermatopathology practice. However, its expression in cutaneous vascular neoplasms, particularly angiosarcomas (AS), remains largely unexplored.

Methods

To further explore PRAME expression in cutaneous AS, 18 cases of post-irradiation and 13 cases of primary cutaneous AS were evaluated for PRAME. For comparison, sections from 11 deep soft tissue/visceral AS, 10 Kaposi sarcomas, 8 microvenular hemangiomas, 7 infantile hemangiomas, 8 atypical vascular lesions, 6 epithelioid hemangioendotheliomas, 6 pyogenic granulomas, 6 papillary endothelial hyperplasias, 6 epithelioid hemangiomas, 3 capillovenous malformations, 3 hobnail hemangiomas, 2 spindle cell hemangiomas, 2 pseudomyogenic hemangioendotheliomas, and 2 composite hemangioendotheliomas were also retrieved.

Results

Overall, 22 of 31 (70.9%; 12 post-irradiation and 10 primary) cutaneous AS were positive for PRAME. In contrast, only 1 of 11 (9.1%) deep soft tissue/visceral AS showed diffuse and strong PRAME nuclear staining. All other tumor types were negative for PRAME, except for 5 of 7 (71.4%) infantile hemangiomas, which demonstrated rare (<5%; four cases) and 1+ (5–25%; one case) nuclear staining.

Conclusions

In this study, we have demonstrated frequent nuclear PRAME expression in cutaneous AS. PRAME immunohistochemistry may serve as a valuable additional marker in selected clinical settings.

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皮肤血管肿瘤中的 PRAME 免疫组化评估显示，原发性和放疗后皮肤血管肉瘤中常出现 PRAME 表达。

背景：黑色素瘤中的优先表达抗原（PRAME）已在皮肤黑色素细胞肿瘤中得到广泛研究，并被证明在常规皮肤病理学实践中具有诊断辅助价值。然而，它在皮肤血管肿瘤，尤其是血管肉瘤（AS）中的表达在很大程度上仍未得到研究：方法：为了进一步探索PRAME在皮肤AS中的表达，我们对18例放射后皮肤AS和13例原发性皮肤AS进行了PRAME评估。此外，还检索到 6 个乳头状内皮增生症、6 个上皮样血管瘤、3 个毛细血管畸形、3 个蹄甲状血管瘤、2 个纺锤形细胞血管瘤、2 个假性肌源性血管内皮瘤和 2 个复合型血管内皮瘤。结果：总体而言，31 例皮肤 AS 中有 22 例（70.9%；12 例为放射后，10 例为原发性）PRAME 阳性。相比之下，11 例深部软组织/内脏 AS 中只有 1 例（9.1%）出现弥漫性强 PRAME 核染色。所有其他类型肿瘤的 PRAME 均为阴性，只有 7 个婴儿血管瘤中的 5 个（71.4%）表现出罕见的 PRAME 阴性：在这项研究中，我们证实了PRAME在皮肤强直性脊柱炎中的频繁核表达。PRAME免疫组化可在特定临床环境中作为一种有价值的额外标记物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cutaneous Pathology 医学-病理学

CiteScore

3.20

自引率

5.90%

发文量

174

审稿时长

3-8 weeks

期刊介绍： Journal of Cutaneous Pathology publishes manuscripts broadly relevant to diseases of the skin and mucosae, with the aims of advancing scientific knowledge regarding dermatopathology and enhancing the communication between clinical practitioners and research scientists. Original scientific manuscripts on diagnostic and experimental cutaneous pathology are especially desirable. Timely, pertinent review articles also will be given high priority. Manuscripts based on light, fluorescence, and electron microscopy, histochemistry, immunology, molecular biology, and genetics, as well as allied sciences, are all welcome, provided their principal focus is on cutaneous pathology. Publication time will be kept as short as possible, ensuring that articles will be quickly available to all interested in this speciality.