Tissue factor pathway inhibitor-2 (TFPI-2)-an underappreciated partaker in cancer and metastasis.

IF 7.7 2区医学 Q1 ONCOLOGY

Cancer and Metastasis Reviews Pub Date : 2024-12-01 Epub Date: 2024-08-17 DOI:10.1007/s10555-024-10205-7

Marek Z Wojtukiewicz, Marta Mysliwiec, Anna Tokajuk, Joanna Kruszewska, Barbara Politynska, Anmbreen Jamroze, Anna M Wojtukiewicz, Dean G Tang, Kenneth V Honn

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引用次数: 0

Abstract

The coagulation system is known to play an important role in cancer development and metastasis, but the precise mechanisms by which it does so remain incompletely understood. With this in mind, we provide an updated overview of the effects of TFPI-2, a protease inhibitor, on cancer development and metastasis. TFPI-2 interacts with the thrombin cascade and also employs other mechanisms to suppress cancer growth and dissemination, which include extracellular matrix stabilization, promotion of caspase-mediated cell apoptosis, inhibition of angiogenesis and transduction of intracellular signals. Down-regulation of TFPI-2 expression is well documented in numerous types of neoplasms, mainly via promoter methylation. However, the exact role of TFPI-2 in cancer progression and possible approaches to up-regulate TFPI-2 expression warrant further studies. Strategies to reactivate TFPI-2 may represent a promising direction for future anticancer studies and therapy development.

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组织因子通路抑制因子-2（TFPI-2）--癌症和转移中一个未被充分重视的参与者。

众所周知，凝血系统在癌症的发展和转移过程中发挥着重要作用，但其确切的作用机制仍不完全清楚。有鉴于此，我们对蛋白酶抑制剂 TFPI-2 对癌症发展和转移的影响进行了最新概述。TFPI-2 与凝血酶级联相互作用，同时还利用其他机制抑制癌症的生长和扩散，这些机制包括稳定细胞外基质、促进卡巴酶介导的细胞凋亡、抑制血管生成和转导细胞内信号。许多类型的肿瘤都存在 TFPI-2 表达下调的情况，主要是通过启动子甲基化。然而，TFPI-2 在癌症进展中的确切作用以及上调 TFPI-2 表达的可能方法还有待进一步研究。重新激活 TFPI-2 的策略可能是未来抗癌研究和疗法开发的一个有前途的方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer and Metastasis Reviews 医学-肿瘤学

CiteScore

17.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Contemporary biomedical research is on the threshold of an era in which physiological and pathological processes can be analyzed in increasingly precise and mechanistic terms.The transformation of biology from a largely descriptive, phenomenological discipline to one in which the regulatory principles can be understood and manipulated with predictability brings a new dimension to the study of cancer and the search for effective therapeutic modalities for this disease. Cancer and Metastasis Reviews provides a forum for critical review and discussion of these challenging developments. A major function of the journal is to review some of the more important and interesting recent developments in the biology and treatment of malignant disease, as well as to highlight new and promising directions, be they technological or conceptual. Contributors are encouraged to review their personal work and be speculative.