A rare cutaneous infection with Mycobacterium chelonae in a pediatric patient treated with trametinib for KRAS-mutated diffuse glioma.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-15 DOI:10.1111/pde.15718

Chenin Ryan, Angel Moore, Matthew Davis, Caitlin Yazel, Shabnam Momtahen, Angela M Ricci, Elizabeth A Talbot, Julianne Mann, Nicole Pace

引用次数: 0

Abstract

Mitogen-activated extracellular signal-regulated kinase inhibitors (MEKi) represent a promising new therapy for pediatric patients with low-grade gliomas, which frequently have abnormal signaling within the mitogen-activated protein kinase (MAP kinase) pathway. However, understanding of long-term efficacy and toxicity is limited in pediatric glioma patients. This article describes a rare presentation of a widespread cutaneous infection with Mycobacterium chelonae in a pediatric patient with a low-grade glioma treated with trametinib.

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一名接受曲美替尼治疗KRAS突变弥漫性胶质瘤的儿童患者罕见地感染了克氏分枝杆菌。

有丝分裂原激活的细胞外信号调节激酶抑制剂（MEKi）是治疗小儿低级别胶质瘤患者的一种前景广阔的新疗法，因为低级别胶质瘤患者经常会出现有丝分裂原激活的蛋白激酶（MAP 激酶）通路信号异常的情况。然而，人们对小儿胶质瘤患者的长期疗效和毒性了解有限。本文描述了一名接受曲美替尼治疗的低级别胶质瘤儿科患者出现广泛皮肤感染克氏分枝杆菌的罕见病例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.