Insights into the cardiovascular benefits of taurine: a systematic review and meta-analysis.

IF 4.4 2区医学 Q1 NUTRITION & DIETETICS

Nutrition Journal Pub Date : 2024-08-15 DOI:10.1186/s12937-024-00995-5

Chih-Chen Tzang, Wei-Chen Lin, Long-Huei Lin, Ting-Yu Lin, Ke-Vin Chang, Wei-Ting Wu, Levent Özçakar

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引用次数: 0

Abstract

Background: Cardiovascular disease (CVD) remains the foremost cause of mortality globally. Taurine, an amino acid, holds promise for cardiovascular health through mechanisms such as calcium regulation, blood pressure reduction, and antioxidant and anti-inflammatory effects. Despite these potential benefits, previous studies have yielded inconsistent results. This meta-analysis of randomized controlled trials (RCTs) aims to evaluate the existing evidence on the quantitative effects of taurine on hemodynamic parameters and cardiac function grading, which are indicative of overall cardiovascular health and performance.

Methods: We conducted an electronic search across multiple databases, including Embase, PubMed, Web of Science, Cochrane CENTRAL, and ClinicalTrials.gov, from their inception to January 2, 2024. Our analysis focused on key cardiovascular outcomes, such as heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular ejection fraction (LVEF), and New York Heart Association (NYHA) Functional Classification. Meta-regression was applied to explore dose-dependent relationships based on the total taurine dose administered during the treatment period. A subgroup analysis, stratified according to the baseline disease status of patients, was also conducted.

Results: The analysis included a pooled sample of 808 participants from 20 randomized controlled trials. Taurine demonstrated a significant reduction in HR (weighted mean difference [WMD] = -3.579 bpm, 95% confidence interval [CI] = -6.044 to -1.114, p = 0.004), SBP (WMD = -3.999 mm Hg, 95% CI = -7.293 to -0.706, p = 0.017), DBP (WMD: -1.435 mm Hg, 95% CI: -2.484 to -0.386, p = 0.007), NYHA (WMD: -0.403, 95% CI: -0.522 to -0.283, p < 0.001), and a significant increase in LVEF (WMD: 4.981%, 95% CI: 1.556 to 8.407, p = 0.004). Meta-regression indicated a dose-dependent reduction in HR (coefficient = -0.0150 per g, p = 0.333), SBP (coefficient = -0.0239 per g, p = 0.113), DBP (coefficient = -0.0089 per g, p = 0.110), and NYHA (coefficient = -0.0016 per g, p = 0.111), and a positive correlation with LVEF (coefficient = 0.0285 per g, p = 0.308). No significant adverse effects were observed compared to controls. In subgroup analysis, taurine significantly improved HR in heart failure patients and healthy individuals. Taurine significantly reduced SBP in healthy individuals, heart failure patients, and those with other diseases, while significantly lowered DBP in hypertensive patients It notably increased LVEF in heart failure patients and improved NYHA functional class in both heart failure patients and those with other diseases.

Conclusions: Taurine showed noteworthy effects in preventing hypertension and enhancing cardiac function. Individuals prone to CVDs may find it advantageous to include taurine in their daily regimen.

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牛磺酸对心血管的益处：系统回顾和荟萃分析。

背景：心血管疾病（CVD）仍然是全球死亡的首要原因。牛磺酸是一种氨基酸，可通过钙调节、降血压、抗氧化和抗炎作用等机制促进心血管健康。尽管牛磺酸具有这些潜在的益处，但以往的研究结果并不一致。这项随机对照试验（RCTs）的荟萃分析旨在评估牛磺酸对血液动力学参数和心脏功能分级的定量影响的现有证据，这些参数和分级是整体心血管健康和性能的指标：我们在多个数据库（包括 Embase、PubMed、Web of Science、Cochrane CENTRAL 和 ClinicalTrials.gov）中进行了电子检索，检索时间从开始到 2024 年 1 月 2 日。我们的分析侧重于主要的心血管结果，如心率（HR）、收缩压（SBP）、舒张压（DBP）、左心室射血分数（LVEF）和纽约心脏协会（NYHA）功能分类。根据治疗期间的牛磺酸总剂量，采用元回归法探索剂量依赖关系。此外，还根据患者的基线疾病状况进行了亚组分析：分析包括来自 20 项随机对照试验的 808 名参与者。牛磺酸能显著降低心率（加权平均差 [WMD] = -3.579 bpm，95% 置信区间 [CI] = -6.044 至 -1.114, p = 0.004）、血压（WMD = -3.999毫米汞柱，95% 置信区间 = -7.293 至 -0.706，P = 0.017）、DBP（WMD：-1.435毫米汞柱，95% 置信区间：-2.484 至 -0.386，P = 0.007）、NYHA（WMD：-0.403，95% 置信区间：-0.522 至 -0.283，P 结论：牛磺酸对心血管疾病有显著疗效：牛磺酸在预防高血压和增强心脏功能方面具有显著效果。容易患心血管疾病的人可能会发现，在日常饮食中加入牛磺酸是有好处的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition Journal NUTRITION & DIETETICS-

CiteScore

9.80

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.