The characteristics and reproducibility of motor speech functional neuroimaging in healthy controls

IF 2.4 3区医学 Q3 NEUROSCIENCES

Frontiers in Human Neuroscience Pub Date : 2024-08-07 DOI:10.3389/fnhum.2024.1382102

Katherine H. Kenyon, Frederique Boonstra, Gustavo Noffs, Angela T. Morgan, Adam P. Vogel, Scott Kolbe, Anneke Van Der Walt

引用次数: 0

Abstract

IntroductionFunctional magnetic resonance imaging (fMRI) can improve our understanding of neural processes subserving motor speech function. Yet its reproducibility remains unclear. This study aimed to evaluate the reproducibility of fMRI using a word repetition task across two time points.MethodsImaging data from 14 healthy controls were analysed using a multi-level general linear model.ResultsSignificant activation was observed during the task in the right hemispheric cerebellar lobules IV-V, right putamen, and bilateral sensorimotor cortices. Activation between timepoints was found to be moderately reproducible across time in the cerebellum but not in other brain regions.DiscussionPreliminary findings highlight the involvement of the cerebellum and connected cerebral regions during a motor speech task. More work is needed to determine the degree of reproducibility of speech fMRI before this could be used as a reliable marker of changes in brain activity.

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健康对照组运动言语功能神经成像的特征和可重复性

导言功能性磁共振成像（fMRI）可以提高我们对运动言语功能神经过程的理解。但其再现性仍不清楚。本研究旨在使用单词重复任务评估两个时间点的 fMRI 重现性。方法使用多层次一般线性模型分析了 14 名健康对照者的成像数据。讨论初步研究结果突显了小脑和相关脑区在运动言语任务中的参与程度。在将言语 fMRI 用作大脑活动变化的可靠标记之前，还需要做更多的工作来确定言语 fMRI 的可重复性程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Human Neuroscience 医学-神经科学

CiteScore

4.70

自引率

6.90%

发文量

830

审稿时长

2-4 weeks

期刊介绍： Frontiers in Human Neuroscience is a first-tier electronic journal devoted to understanding the brain mechanisms supporting cognitive and social behavior in humans, and how these mechanisms might be altered in disease states. The last 25 years have seen an explosive growth in both the methods and the theoretical constructs available to study the human brain. Advances in electrophysiological, neuroimaging, neuropsychological, psychophysical, neuropharmacological and computational approaches have provided key insights into the mechanisms of a broad range of human behaviors in both health and disease. Work in human neuroscience ranges from the cognitive domain, including areas such as memory, attention, language and perception to the social domain, with this last subject addressing topics, such as interpersonal interactions, social discourse and emotional regulation. How these processes unfold during development, mature in adulthood and often decline in aging, and how they are altered in a host of developmental, neurological and psychiatric disorders, has become increasingly amenable to human neuroscience research approaches. Work in human neuroscience has influenced many areas of inquiry ranging from social and cognitive psychology to economics, law and public policy. Accordingly, our journal will provide a forum for human research spanning all areas of human cognitive, social, developmental and translational neuroscience using any research approach.