Anticancer potential of decursin, decursinol angelate, and decursinol from Angelica gigas Nakai: A comprehensive review and future therapeutic prospects

IF 3.5 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Food Science & Nutrition Pub Date : 2024-07-31 DOI:10.1002/fsn3.4376

Simona Sestito, Roberta Ibba, Federico Riu, Sara Carpi, Antonio Carta, Clementina Manera, Solomon Habtemariam, Balakyz Yeskaliyeva, Zainab M. Almarhoon, Javad Sharifi-Rad, Simona Rapposelli

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Abstract

Many naturally derived compounds are currently used in oncotherapy. Besides official medicine, complementary and alternative medicine practices, including old herbal remedies, are widely used and accepted as additional tools in cancer treatment. Angelica gigas Nakai (AGN), a medicinal herb in Asia, has roots historically used in medicine. This review focuses on key bioactive compounds from AGN roots – decursin, decursinol angelate (DA), and decursinol (DOH). Exploring their source, biosynthesis, and therapeutic mechanisms, the review highlights their role in cancer treatment. Biotechnological strategies for enhanced production and semisynthetic derivatives with anticancer properties are discussed. The study emphasizes the promising pharmacological potential of decursin, DA, and DOH in various therapeutic applications, particularly cancer treatment. The review also underscores innovative approaches to increase production and explores semisynthetic derivatives as a promising avenue for future natural product-based drug discovery. This concise overview provides valuable insights into the potential of AGN-derived compounds in the field of natural product-based therapeutics.

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来自中居当归的蜕皮素、蜕皮素醇当归酸酯和蜕皮素醇的抗癌潜力：全面回顾与未来治疗前景

目前，许多天然提取的化合物被用于肿瘤治疗。除官方药物外，补充和替代医学疗法，包括古老的草药疗法，也被广泛应用于癌症治疗，并被接受为癌症治疗的补充工具。当归（Angelica gigas Nakai，AGN）是亚洲的一种药材，其根部在历史上曾被用于医药。本综述重点介绍 AGN 根部的主要生物活性化合物--蜕皮素、蜕皮醇天使酸酯（DA）和蜕皮醇（DOH）。本综述探讨了它们的来源、生物合成和治疗机制，重点介绍了它们在癌症治疗中的作用。还讨论了提高产量的生物技术策略和具有抗癌特性的半合成衍生物。研究强调了去甲斑蝥素、DA 和 DOH 在各种治疗应用（尤其是癌症治疗）中的巨大药理潜力。该综述还强调了提高产量的创新方法，并探讨了半合成衍生物作为未来基于天然产品的药物发现的一种前景广阔的途径。这篇简明扼要的综述为了解 AGN 衍生化合物在基于天然产物的治疗领域的潜力提供了宝贵的见解。

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来源期刊

Food Science & Nutrition Agricultural and Biological Sciences-Food Science

CiteScore

7.40

自引率

5.10%

发文量

434

审稿时长

24 weeks

期刊介绍： Food Science & Nutrition is the peer-reviewed journal for rapid dissemination of research in all areas of food science and nutrition. The Journal will consider submissions of quality papers describing the results of fundamental and applied research related to all aspects of human food and nutrition, as well as interdisciplinary research that spans these two fields.