Maomao He , Ming Xiao , Ran Wang, Jiangli Fan, Xiaojun Peng, Wen Sun
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引用次数: 0
Abstract
Phototherapy, referring to photodynamic/photothermal therapy, has been extensively validated to promote enhanced immunotherapeutic effects by stimulating tumor cell immunogenic death. Photoimmunotherapy has been persistently investigated to establish potent antitumor effects against primary and distant tumors, synchronously eliciting powerful immunological memory effects, thus ultimately preventing and eradicating rechallenged tumors. Phototherapeutic nanoagents play essential roles in ensuring the sufficient efficacy of photoimmunotherapy, which provides a flexible platform to integrate multifunctional types of phototherapy into a single platform. In particular, tailored nanoparticles are available to amplify tumor immunogenicity and to modulate the immunosuppressive tumor microenvironment simultaneously and spatiotemporally for the treatment of cancers. In this review, we summarized commonly adopted strategies to achieve enhanced cancer immunotherapies induced by conventionally designed phototherapeutic nanoagents. We also analyzed the immunotherapeutic performance and characteristics of phototherapy in detail. The manuscript implies our thoughts on the following aspects: directional design of photosensitizing agents, functional construction of nanomedicines, rational modulation of immunotherapy, and augmented phototherapeutic effects.
期刊介绍:
Progress in Materials Science is a journal that publishes authoritative and critical reviews of recent advances in the science of materials. The focus of the journal is on the fundamental aspects of materials science, particularly those concerning microstructure and nanostructure and their relationship to properties. Emphasis is also placed on the thermodynamics, kinetics, mechanisms, and modeling of processes within materials, as well as the understanding of material properties in engineering and other applications.
The journal welcomes reviews from authors who are active leaders in the field of materials science and have a strong scientific track record. Materials of interest include metallic, ceramic, polymeric, biological, medical, and composite materials in all forms.
Manuscripts submitted to Progress in Materials Science are generally longer than those found in other research journals. While the focus is on invited reviews, interested authors may submit a proposal for consideration. Non-invited manuscripts are required to be preceded by the submission of a proposal. Authors publishing in Progress in Materials Science have the option to publish their research via subscription or open access. Open access publication requires the author or research funder to meet a publication fee (APC).
Abstracting and indexing services for Progress in Materials Science include Current Contents, Science Citation Index Expanded, Materials Science Citation Index, Chemical Abstracts, Engineering Index, INSPEC, and Scopus.