Isoliquiritigenin Alleviates Diabetic Kidney Disease via Oxidative Stress and the TLR4/NF-κB/NLRP3 Inflammasome Pathway

IF 4.5 2区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY
Yanhong Wang, Jia Yang, Xinyue Chang, Yuan Xue, Gaohong Liu, Tingting Zhang, Weihao Chen, Weiping Fan, Jihua Tian, Xiaojun Ren
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Abstract

Diabetic kidney disease (DKD) is the primary factor that causes chronic kidney disease and causes increasing mortality and morbidity due to its severe consequences. Isoliquiritigenin (ISL) is the primary element of licorice root that is physiologically active and has antifree radical, antioxidation, and antiapoptotic properties. However, the effect of ISL on DKD is still unclear and needs to be further improved. This study aims to evaluate the renoprotective effects of ISL on diabetes-induced renal injury and explores the underlying mechanisms involved. Male C57BL/6 mice are fed a high-fat diet and then injected with streptozotocin for 2 consecutive days to establish a diabetic model, and high-glucose-treated NRK-52E cells are used to investigate the renoprotective effects of ISL in DKD. The results show that ISL significantly preserves renal function and architecture in DKD. ISL suppresses oxidative stress and reduces ROS levels, inhibiting the activation of the NF-κB and the NLRP3 inflammasome and the occurrence of pyroptosis. Moreover, the study finds that ISL can inhibit the mitochondrial apoptotic pathway. In addition, the study confirms the inhibitory effect of ISL on the TLR4/NF-κB/NLRP3 inflammasome pathway. These observations demonstrate that the natural flavonoid compound ISL can be a promising agent for the treatment of DKD.

Abstract Image

Abstract Image

Isoliquiritigenin 通过氧化应激和 TLR4/NF-κB/NLRP3 炎症组通路缓解糖尿病肾病
糖尿病肾病(DKD)是引起慢性肾病的主要因素,其严重后果导致死亡率和发病率不断上升。异桔梗甙元(ISL)是甘草根中具有生理活性的主要成分,具有抗自由基、抗氧化和抗细胞凋亡的特性。然而,ISL 对 DKD 的影响仍不明确,有待进一步改善。本研究旨在评估 ISL 对糖尿病诱导的肾损伤的肾保护作用,并探讨其潜在机制。雄性C57BL/6小鼠以高脂肪饮食喂养,然后连续2天注射链脲佐菌素建立糖尿病模型,并使用高葡萄糖处理的NRK-52E细胞研究ISL在DKD中的肾保护作用。结果表明,ISL能明显保护DKD患者的肾功能和结构。ISL可抑制氧化应激,降低ROS水平,抑制NF-κB和NLRP3炎性体的活化,以及热蛋白沉积的发生。此外,研究还发现 ISL 能抑制线粒体凋亡途径。此外,研究还证实了 ISL 对 TLR4/NF-κB/NLRP3 炎性体途径的抑制作用。这些观察结果表明,天然类黄酮化合物ISL是一种治疗DKD的有效药物。
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来源期刊
Molecular Nutrition & Food Research
Molecular Nutrition & Food Research 工程技术-食品科技
CiteScore
8.70
自引率
1.90%
发文量
250
审稿时长
1.7 months
期刊介绍: Molecular Nutrition & Food Research is a primary research journal devoted to health, safety and all aspects of molecular nutrition such as nutritional biochemistry, nutrigenomics and metabolomics aiming to link the information arising from related disciplines: Bioactivity: Nutritional and medical effects of food constituents including bioavailability and kinetics. Immunology: Understanding the interactions of food and the immune system. Microbiology: Food spoilage, food pathogens, chemical and physical approaches of fermented foods and novel microbial processes. Chemistry: Isolation and analysis of bioactive food ingredients while considering environmental aspects.
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