Patient-specific arterial wall generation for intracranial aneurysms with a variable and a near realistic vessel wall thickness for FSI studies

IF 1.7 4区 医学 Q3 ENGINEERING, BIOMEDICAL
Srinivas Bolem , Chanikya Valeti , Nimmy Thankom Philip , B.J. Sudhir , B.S.V. Patnaik
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引用次数: 0

Abstract

Background and Objective

Imaging methodologies such as, computed tomography (CT) aid in three-dimensional (3D) reconstruction of patient-specific aneurysms. The radiological data is useful in understanding their location, shape, size, and disease progression. However, there are serious impediments in discerning the blood vessel wall thickness due to limitations in the current imaging modalities. This further restricts the ability to perform high-fidelity fluid structure interaction (FSI) studies for an accurate assessment of rupture risk. FSI studies would require the arterial wall mesh to be generated to determine realistic maximum allowable wall stresses by performing coupled calculations for the hemodynamic forces with the arterial walls.

Methods

In the present study, a novel methodology is developed to geometrically model variable vessel wall thickness for the lumen isosurface extracted from CT scan slices of patient-specific aneurysms based on clinical and histopathological inputs. FSI simulations are carried out with the reconstructed models to assess the importance of near realistic wall thickness model on rupture risk predictions.

Results

During surgery, clinicians often observe translucent vessel walls, indicating the presence of thin regions. The need to generate variable vessel wall thickness model, that embodies the wall thickness gradation, is closer to such clinical observations. Hence, corresponding FSI simulations performed can improve clinical outcomes. Considerable differences in the magnitude of instantaneous wall shear stresses and von Mises stresses in the walls of the aneurysm was observed between a uniform wall thickness and a variable wall thickness model.

Conclusion

In the present study, a variable vessel wall thickness generation algorithm is implemented. It was shown that, a realistic wall thickness modeling is necessary for an accurate prediction of the shear stresses on the wall as well as von Mises stresses in the wall. FSI simulations are performed to demonstrate the utility of variable wall thickness modeling.

Abstract Image

针对特定患者生成颅内动脉瘤的动脉壁,为 FSI 研究提供可变且接近真实的血管壁厚度
背景和目的计算机断层扫描(CT)等成像方法有助于患者特定动脉瘤的三维(3D)重建。放射学数据有助于了解动脉瘤的位置、形状、大小和疾病进展。然而,由于目前成像模式的局限性,在辨别血管壁厚度方面存在严重障碍。这进一步限制了进行高保真流体结构相互作用(FSI)研究以准确评估破裂风险的能力。FSI 研究需要生成动脉壁网格,通过对动脉壁的血液动力进行耦合计算来确定现实的最大容许壁应力。方法在本研究中,根据临床和组织病理学输入,开发了一种新方法来为从特定患者动脉瘤 CT 扫描切片中提取的管腔等表面的可变血管壁厚度建立几何模型。使用重建的模型进行 FSI 模拟,以评估接近真实的壁厚模型对破裂风险预测的重要性。需要生成可变的血管壁厚度模型,以体现血管壁厚度的渐变,这更接近临床观察结果。因此,进行相应的 FSI 模拟可以改善临床结果。在均匀壁厚模型和可变壁厚模型之间,观察到动脉瘤壁的瞬时壁剪应力和 von Mises 应力的大小存在很大差异。研究表明,要准确预测血管壁上的剪应力和血管壁上的 von Mises 应力,就必须建立切合实际的壁厚模型。为了证明可变壁厚建模的实用性,我们进行了 FSI 模拟。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Medical Engineering & Physics
Medical Engineering & Physics 工程技术-工程:生物医学
CiteScore
4.30
自引率
4.50%
发文量
172
审稿时长
3.0 months
期刊介绍: Medical Engineering & Physics provides a forum for the publication of the latest developments in biomedical engineering, and reflects the essential multidisciplinary nature of the subject. The journal publishes in-depth critical reviews, scientific papers and technical notes. Our focus encompasses the application of the basic principles of physics and engineering to the development of medical devices and technology, with the ultimate aim of producing improvements in the quality of health care.Topics covered include biomechanics, biomaterials, mechanobiology, rehabilitation engineering, biomedical signal processing and medical device development. Medical Engineering & Physics aims to keep both engineers and clinicians abreast of the latest applications of technology to health care.
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