Structural difference analysis of gut microbiota in different bone mass populations and relevant probiotic (lactobacilli) supplementation strategies

IF 7.4 Q1 FOOD SCIENCE & TECHNOLOGY
Food frontiers Pub Date : 2024-07-22 DOI:10.1002/fft2.449
Jiani Pan, Pingping Yin, Leilei Yu, Heng Zhang, Chengcheng Zhang, Jianxin Zhao, Fengwei Tian, Qixiao Zhai
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Abstract

Disruption of the bone metabolic balance with advancing age leads to an escalating prevalence of bone-related diseases, significantly compromising individuals’ quality of life. The gut microbiota actively participates in the regulation of bone metabolism, and perturbations in the gut microbiota can exacerbate bone diseases by compromising gut barrier integrity. Determining the microbial taxa involved in bone loss could offer valuable insights into the development of alternative therapies and nutritional interventions for disease management. Therefore, based on metagenomic and 16S ribosomal RNA data, this study analyzed the gut microbiota structure of 488 individuals with different bone masses (NC, normal; ON, osteopenia; OP, osteoporosis) to identify significant associations between the gut microbiota and bone loss. The results showed that at the genus and species levels, the microbiota diversity of the ON population increased, whereas that of the OP population decreased. Bacteroides were significantly enriched in the OP population, whereas the beneficial bacteria Bifidobacterium, Akkermansia, and lactobacilli decreased. Subsequent analyses revealed no significant variation in different bone populations in terms of Bifidobacterium levels, whereas lactobacilli exhibited diverse responses across distinct bone populations. The administration of lactobacilli effectively enhanced lumbar spine bone mineral density and modulated the gut microbiota structure in a population with unhealthy bone mass. This study contributes to the validation of the association between the gut microbiota and bone mass, enhances our understanding of the potential impact of probiotics (lactobacilli) on bone mass, and establishes a robust scientific basis for the application of probiotics in the regulation of bone mass.

Abstract Image

不同骨量人群肠道微生物群结构差异分析及相关益生菌(乳酸菌)补充策略
随着年龄的增长,骨代谢平衡受到破坏,导致骨相关疾病的发病率不断上升,严重影响个人的生活质量。肠道微生物群积极参与骨代谢的调节,而肠道微生物群的紊乱会损害肠道屏障的完整性,从而加剧骨病。确定参与骨质流失的微生物类群可为开发替代疗法和疾病管理营养干预措施提供有价值的见解。因此,本研究基于元基因组和 16S 核糖体 RNA 数据,分析了 488 名不同骨质(NC,正常;ON,骨质疏松症;OP,骨质疏松症)个体的肠道微生物群结构,以确定肠道微生物群与骨质流失之间的显著关联。结果显示,在属和种水平上,ON人群的微生物群多样性增加,而OP人群的微生物群多样性减少。在 OP 群体中,乳杆菌明显增多,而有益菌双歧杆菌、Akkermansia 和乳杆菌则有所减少。随后的分析表明,不同骨群的双歧杆菌水平没有明显差异,而乳酸杆菌在不同骨群中表现出不同的反应。服用乳酸菌能有效提高腰椎骨矿物质密度,并调节骨质不健康人群的肠道微生物群结构。这项研究有助于验证肠道微生物群与骨量之间的关系,加深我们对益生菌(乳酸菌)对骨量的潜在影响的理解,并为益生菌在骨量调节中的应用奠定坚实的科学基础。
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来源期刊
CiteScore
10.50
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0.00%
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审稿时长
10 weeks
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