High composite dietary antioxidant index is associated with reduced risk of kidney stones: a cross-sectional analysis of NHANES 2007-2020

IF 3.4 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research Pub Date : 2024-08-01 DOI:10.1016/j.nutres.2024.06.006

Anwen Huang , Weiyan Huang , Yufei Ye , Lulu Liu , Haiyan Wang , Xiaolu Bian , Yingyi Qin , Zhiyong Guo , Wei Chen

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Abstract

The composite dietary antioxidant index (CDAI) is commonly utilized to assess antioxidant intake across diseases, but its association with kidney stones is unclear. We hypothesized that higher CDAI is associated with reduced kidney stone risk. Using National Health and Nutrition Examination Survey 2007-2020 data, we calculated CDAI based on vitamins A, C, E, selenium, zinc, and carotenoids intake in 29,280 adults. Stone formers had lower CDAI, with significant gender differences. Restricted cubic spline showed an L-shaped curve, with the steepest decline before CDAI of 1.449. In multivariate logistic regression, moderate and high CDAI tertiles were associated with reduced kidney stone odds compared to the lowest tertile (odds ratio [95% CI]): 0.85 [0.73, 0.99], P = .035 and 0.80 [0.66, 0.95], P = .014, respectively). Vitamin C had the highest negative correlation weight with kidney stones. Significant interactions were found for age and diabetes subgroups. In conclusion, higher CDAI may reduce kidney stone risk, especially with adequate vitamin C intake. Further cohort studies are warranted to confirm the causal association.

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高复合膳食抗氧化指数与降低肾结石风险有关：对 2007-2020 年 NHANES 的横断面分析。

膳食抗氧化剂综合指数（CDAI）通常用于评估各种疾病的抗氧化剂摄入量，但其与肾结石的关系尚不清楚。我们假设，CDAI越高，肾结石风险越低。我们利用 2007-2020 年全国健康与营养调查数据，根据 29,280 名成年人的维生素 A、C、E、硒、锌和类胡萝卜素摄入量计算出 CDAI。结石形成者的 CDAI 较低，性别差异显著。限制性三次样条曲线显示出一条 L 型曲线，CDAI 下降幅度最大，为 1.449。在多变量逻辑回归中，与最低三等分位数相比，中度和高度 CDAI 三等分位数与肾结石几率降低相关（几率比 [95% CI]）：分别为 0.85 [0.73, 0.99]，P = .035 和 0.80 [0.66, 0.95]，P = .014）。维生素 C 与肾结石的负相关权重最高。年龄和糖尿病亚组之间存在显著的交互作用。总之，较高的 CDAI 可降低肾结石风险，尤其是在维生素 C 摄入充足的情况下。为证实两者之间的因果关系，有必要开展进一步的队列研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition Research 医学-营养学

CiteScore

7.60

自引率

2.20%

发文量

107

审稿时长

58 days

期刊介绍： Nutrition Research publishes original research articles, communications, and reviews on basic and applied nutrition. The mission of Nutrition Research is to serve as the journal for global communication of nutrition and life sciences research on diet and health. The field of nutrition sciences includes, but is not limited to, the study of nutrients during growth, reproduction, aging, health, and disease. Articles covering basic and applied research on all aspects of nutrition sciences are encouraged, including: nutritional biochemistry and metabolism; metabolomics, nutrient gene interactions; nutrient requirements for health; nutrition and disease; digestion and absorption; nutritional anthropology; epidemiology; the influence of socioeconomic and cultural factors on nutrition of the individual and the community; the impact of nutrient intake on disease response and behavior; the consequences of nutritional deficiency on growth and development, endocrine and nervous systems, and immunity; nutrition and gut microbiota; food intolerance and allergy; nutrient drug interactions; nutrition and aging; nutrition and cancer; obesity; diabetes; and intervention programs.