Antioxidant activity of Bougainvillea spectabilis ethanol extracts as an aryl hydrocarbon inhibitor

IF 0.5 Q4 EDUCATION, SCIENTIFIC DISCIPLINES

Pharmacy Education Pub Date : 2024-07-07 DOI:10.46542/pe.2024.243.395400

Ni Nyoman Yuliani, T. Erawati, Jefrin Sambara, Muhamad Satria, Pua Upa

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引用次数: 0

Abstract

Background: Antioxidants overcome ageing processes and skin tissue damage caused by free radicals. The flavonoid contents of Bougainvillea spectabilis Willd contain hydroxyl groups attached to the carbon of the aromatic rings which makes them capable of catching free radicals and absorbing UV-A and UV-B. Objective: This study aimed to investigate the in silico antioxidant activities of various compounds contained in B. spectabilis Willd ethanol extracts compared to control. Method: The identification was carried out using GCMS methods and Molegro Virtual Docker. The molecular mechanics of scoring functions used in this study were the Rerank score, Root Mean Standard Deviation, and H Bond Result: p-Trimethylsylyoxylphenyl-(trimethylsilyoxy)trimethylsilyacrilate had a better bond than vitamin C used as the control and is smaller than BHF_401 (A) standard ligand, indicated by rerank scores of -92.6478, -76.0593, and -104.771. Conclusion: p-Trimethylsilyloxyphenyl-(trimethylsilyloxy)trimethylsilylacrylate had a better and more stable bond (rerank score: -92.6478) than the positive vitamin C control (76.0593).

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作为芳基烃抑制剂的九重葛乙醇提取物的抗氧化活性

背景：抗氧化剂能克服自由基引起的老化过程和皮肤组织损伤。九重葛中的黄酮类化合物含有连接在芳香环碳上的羟基，因此能够捕捉自由基并吸收紫外线-A 和紫外线-B。研究目的本研究旨在研究与对照组相比，九重葛乙醇提取物中所含各种化合物的抗氧化活性。研究方法：采用 GCMS 方法和 Molegro Virtual Docker 进行鉴定。本研究中使用的分子力学评分函数为 Rerank 分数、均值根标准偏差和 H 键结果：对三甲基硅氧基苯基-(三甲基硅氧基)三甲基硅吖啶酸酯的键比用作对照的维生素 C 好，且小于 BHF_401 (A)标准配体，Rerank 分数分别为 -92.6478、-76.0593 和 -104.771。结论：对-三甲基硅氧基苯基-(三甲基硅氧基)三甲基硅基丙烯酸酯比阳性维生素 C 对照（76.0593）的键更好、更稳定（rerank 分数：-92.6478）。

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来源期刊

Pharmacy Education EDUCATION, SCIENTIFIC DISCIPLINES-

CiteScore

0.80

自引率

20.00%

发文量

174

期刊介绍： Pharmacy Education journal provides a research, development and evaluation forum for communication between academic teachers, researchers and practitioners in professional and pharmacy education, with an emphasis on new and established teaching and learning methods, new curriculum and syllabus directions, educational outcomes, guidance on structuring courses and assessing achievement, and workforce development. It is a peer-reviewed online open access platform for the dissemination of new ideas in professional pharmacy education and workforce development. Pharmacy Education supports Open Access (OA): free, unrestricted online access to research outputs. Readers are able to access the Journal and individual published articles for free - there are no subscription fees or ''pay per view'' charges. Authors wishing to publish their work in Pharmacy Education do so without incurring any financial costs.