Clinicopathologic features of pityriasis rosea-like drug eruption secondary to imatinib: A case report and review of the literature

IF 1.6 4区 医学 Q3 DERMATOLOGY
Joseph S. Durgin MD, Carli P. Whittington MD, Jane Harrell MD, Julie E. Mervak MD, Emily H. Smith MD
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Abstract

Pityriasis rosea is an acute, self-limited exanthem that typically occurs in adolescence and young adulthood, classically featuring ovoid erythematous and scaly lesions on the trunk and proximal extremities. While its cause is not definitively known, the classic form of pityriasis rosea may result from the reactivation of latent human herpesvirus (HHV) infections (HHV-6 and HHV-7). Interestingly, drug eruptions that clinically and/or histopathologically resemble pityriasis rosea have also been reported. These pityriasis rosea-like drug eruptions tend to occur at an older age and have a shorter duration than the classic type. As there are different management paradigms, the distinction between classic pityriasis rosea and the mimicking drug eruption is important to recognize. Herein, we report a case of a pityriasis rosea-like drug eruption that occurred in association with imatinib mesylate treatment for chronic myeloid leukemia. We also review the clinicopathologic features of reported cases of pityriasis rosea-like drug eruption, including those due to imatinib. While the clinical morphology of the cutaneous drug-related eruption mimics the lesions seen in classic pityriasis rosea, the presence of unique histopathologic findings, including necrotic keratinocytes, interface dermatitis, and eosinophils, may aid in distinction.

继发于伊马替尼的玫瑰糠疹样药物疹的临床病理特征:病例报告和文献综述。
玫瑰糠疹是一种急性、自限性外伤,通常发生在青春期和青年期,典型特征是躯干和四肢近端出现卵圆形红斑和鳞屑。虽然病因尚不明确,但典型的玫瑰糠疹可能是潜伏的人类疱疹病毒(HHV)感染(HHV-6 和 HHV-7)再次激活所致。有趣的是,临床和/或组织病理学上与玫瑰糠疹相似的药物疹也有报道。与典型的玫瑰糠疹相比,这些玫瑰糠疹样药物疹的发病年龄更大,持续时间更短。由于存在不同的治疗范例,因此必须认识到典型玫瑰糠疹和仿药疹之间的区别。在此,我们报告了一例与甲磺酸伊马替尼治疗慢性髓性白血病相关的玫瑰糠疹样药物疹。我们还回顾了已报道的玫瑰糠疹样药物疹病例的临床病理特征,包括那些由伊马替尼引起的病例。虽然皮肤药物相关疹的临床形态与典型玫瑰糠疹的皮损相似,但其独特的组织病理学发现(包括坏死的角质细胞、界面皮炎和嗜酸性粒细胞)可能有助于鉴别。
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来源期刊
CiteScore
3.20
自引率
5.90%
发文量
174
审稿时长
3-8 weeks
期刊介绍: Journal of Cutaneous Pathology publishes manuscripts broadly relevant to diseases of the skin and mucosae, with the aims of advancing scientific knowledge regarding dermatopathology and enhancing the communication between clinical practitioners and research scientists. Original scientific manuscripts on diagnostic and experimental cutaneous pathology are especially desirable. Timely, pertinent review articles also will be given high priority. Manuscripts based on light, fluorescence, and electron microscopy, histochemistry, immunology, molecular biology, and genetics, as well as allied sciences, are all welcome, provided their principal focus is on cutaneous pathology. Publication time will be kept as short as possible, ensuring that articles will be quickly available to all interested in this speciality.
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