Oncocytic/Hürthle cell lesions have the same implied risk of neoplasm/malignancy as their follicular counterparts

IF 1.2 4区医学 Q4 CELL BIOLOGY

Cytopathology Pub Date : 2024-07-16 DOI:10.1111/cyt.13424

Diana Lin, C. Alexandra Hanna, Andra Frost, Allison Wrenn, Isam Eltoum

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引用次数: 0

Abstract

Introduction

There are conflicting results on whether the presence of oncocytes modifies the risk of neoplasm (RON) or malignancy (ROM) for thyroid fine-needle aspirates (FNAs): Atypia of undetermined significance AUS and Follicular Neoplasm, FN, or Oncocytic Neoplasm, ON. To our knowledge, the effect of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) has not yet been studied. We compared RON and ROM between follicular type AUS (AUS-FT) and oncocytic type AUS (AUS-OT) and between FN and ON.

Materials and Methods

We retrospectively analysed all thyroid FNAs with the diagnostic category of AUS-other or Neoplasm (2005–2015). AUS-FT had predominance of microfollicles and AUS-OT had predominance of oncocytes. Histology follow-up was then reviewed and RON, ROM was then calculated and compared (significant at p < 0.05). We repeated the search for 2018 to evaluate for NIFTP effect.

Results

Pre-NIFTP, 859/5063 cases (17%) were AUS-FT, AUS-OT, FN, and ON. Histology follow-up was available for 297 cases (35%). RON was 83/183 (45%) for AUS-FT, 35/76 (46%) for AUS-OT, 15/25 (60%) for FN and 11/13 (85%) for ON. Post-NIFTP, RON was 11/31 (35%) for AUS-FT, 5/8 (63%) for AUS-OT, 1/2 (50%) for FN and 4/5 (80%) for ON. For both periods, RON, ROM of AUS-FT was not significantly different than AUS-OT, and no significant differences were observed comparing FN and ON.

Conclusion

The predominance of oncocytes does not modify the implied RON, ROM for categories of AUS or FN\ON, even after the adoption of NIFTP.

Abstract Image

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肿瘤细胞/Hürthle 细胞病变与滤泡性病变具有相同的肿瘤/恶性肿瘤隐含风险。

导言：关于癌细胞的存在是否会改变甲状腺细针穿刺（FNA）的肿瘤（RON）或恶性（ROM）风险，目前尚存在相互矛盾的结果：意义未定的不典型性（AUS）和滤泡性肿瘤（FN）或肿瘤细胞性肿瘤（ON）。据我们所知，目前尚未研究过具有乳头状核特征的非侵袭性甲状腺滤泡性肿瘤（NIFTP）的影响。我们比较了滤泡型甲状腺瘤（AUS-FT）和肿瘤细胞型甲状腺瘤（AUS-OT）之间以及FN和ON之间的RON和ROM：我们对所有诊断类别为AUS-其他或肿瘤（2005-2015年）的甲状腺FNA进行了回顾性分析。AUS-FT以微滤泡为主，AUS-OT以肿瘤细胞为主。然后对组织学随访进行复查，计算并比较 RON、ROM（以 p 为显著结果）：NIFTP前，859/5063例（17%）为AUS-FT、AUS-OT、FN和ON。297例（35%）获得了组织学随访。AUS-FT的RON为83/183（45%），AUS-OT为35/76（46%），FN为15/25（60%），ON为11/13（85%）。NIFTP 后，RON 在 AUS-FT 为 11/31（35%），AUS-OT 为 5/8（63%），FN 为 1/2 （50%），ON 为 4/5（80%）。在这两个时期，AUS-FT的RON、ROM与AUS-OT没有明显差异，FN和ON也没有明显差异：结论：即使在采用 NIFTP 后，肿瘤细胞的优势也不会改变 AUS 或 FN\ON 类别的隐含 RON、ROM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytopathology 生物-病理学

CiteScore

2.30

自引率

15.40%

发文量

107

审稿时长

6-12 weeks

期刊介绍： The aim of Cytopathology is to publish articles relating to those aspects of cytology which will increase our knowledge and understanding of the aetiology, diagnosis and management of human disease. It contains original articles and critical reviews on all aspects of clinical cytology in its broadest sense, including: gynaecological and non-gynaecological cytology; fine needle aspiration and screening strategy. Cytopathology welcomes papers and articles on: ultrastructural, histochemical and immunocytochemical studies of the cell; quantitative cytology and DNA hybridization as applied to cytological material.