Characterizing drug-induced epidermal necrolysis in a pediatric cohort.

IF 1.2 4区医学 Q3 DERMATOLOGY

Pediatric Dermatology Pub Date : 2024-07-09 DOI:10.1111/pde.15693

Ariel B Brown, Andrew J Park, Nnenna G Agim, Katherine A Gordon

引用次数: 0

Abstract

This study aims to characterize the timeline and clinical features of onset, progression, and management of drug-induced epidermal necrolysis in pediatric patients. Sixteen pediatric patients were retrospectively identified and selected if under age 18 years at admission with one identified culprit drug exposure. Culprit drugs were antiepileptics (12/16, 75%) and antibiotics (4/16, 25%). Notably, anti-epileptic drugs (AED) had delayed onset and reported dose escalations that precipitated symptom onset; thus, patients prescribed AED with or without planned dose escalations should be monitored for prodromal symptoms longer than the typical onset window.

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儿科群体中药物诱发表皮坏死症的特征。

本研究旨在描述儿科患者药物性表皮坏死症的发病时间和临床特征、病情发展和处理方法。通过回顾性研究发现，16 名儿科患者入院时未满 18 周岁，且已确定接触过一种罪魁祸首药物。罪魁祸首药物为抗癫痫药（12/16，75%）和抗生素（4/16，25%）。值得注意的是，抗癫痫药物（AED）的起效时间较晚，且有报告称剂量增加会导致症状发作；因此，无论是否计划增加剂量，都应监测开具 AED 处方的患者是否出现比典型起效时间更长的前驱症状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Dermatology 医学-皮肤病学

CiteScore

3.20

自引率

6.70%

发文量

269

审稿时长

1 months

期刊介绍： Pediatric Dermatology answers the need for new ideas and strategies for today''s pediatrician or dermatologist. As a teaching vehicle, the Journal is still unsurpassed and it will continue to present the latest on topics such as hemangiomas, atopic dermatitis, rare and unusual presentations of childhood diseases, neonatal medicine, and therapeutic advances. As important progress is made in any area involving infants and children, Pediatric Dermatology is there to publish the findings.