Correlation between serum trimethylamine-N-oxide and body fat distribution in middle-aged and older adults: a prospective cohort study.

IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS
Si Chen, Xiao-Yan Chen, Zi-Hui Huang, Ai-Ping Fang, Shu-Yi Li, Rong-Zhu Huang, Yu-Ming Chen, Bi-Xia Huang, Hui-Lian Zhu
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引用次数: 0

Abstract

Background: Trimethylamine-N-oxide (TMAO) is linked with obesity, while limited evidence on its relationship with body fat distribution. Herein, we investigated the associations between serum TMAO and longitudinal change of fat distribution in this prospective cohort study.

Methods: Data of 1964 participants (40-75y old) from Guangzhou Nutrition and Health Study (GNHS) during 2008-2014 was analyzed. Serum TMAO concentration was quantified by HPLC-MS/MS at baseline. The body composition was assessed by dual-energy X-ray absorptiometry at each 3-y follow-up. Fat distribution parameters were fat-to-lean mass ratio (FLR) and trunk-to-leg fat ratio (TLR). Fat distribution changes were derived from the coefficient of linear regression between their parameters and follow-up duration.

Results: After an average of 6.2-y follow-up, analysis of covariance (ANCOVA) and linear regression displayed women with higher serum TMAO level had greater increments in trunk FLR (mean ± SD: 1.47 ± 4.39, P-trend = 0.006) and TLR (mean ± SD: 0.06 ± 0.24, P-trend = 0.011). Meanwhile, for women in the highest TMAO tertile, linear mixed-effects model (LMEM) analysis demonstrated the annual estimated increments (95% CI) were 0.03 (95% CI: 0.003 - 0.06, P = 0.032) in trunk FLR and 1.28 (95% CI: -0.17 - 2.73, P = 0.083) in TLR, respectively. In men, there were no similar significant observations. Sensitivity analysis yielded consistent results.

Conclusion: Serum TMAO displayed a more profound correlation with increment of FLR and TLR in middle-aged and older community-dwelling women in current study. More and further studies are still warranted in the future.

Trial registration: NCT03179657.

中老年人血清三甲胺-N-氧化物与体内脂肪分布的相关性:一项前瞻性队列研究。
背景:三甲胺-N-氧化物(TMAO)与肥胖有关,但其与体内脂肪分布关系的证据有限。在这项前瞻性队列研究中,我们探讨了血清 TMAO 与脂肪分布纵向变化之间的关系:方法:分析 2008-2014 年期间广州营养与健康研究(GNHS)中 1964 名参与者(40-75 岁)的数据。采用 HPLC-MS/MS 对基线血清 TMAO 浓度进行定量。每3年随访一次,采用双能X射线吸收测定法评估身体成分。脂肪分布参数为脂肪与瘦体重比(FLR)和躯干与腿部脂肪比(TLR)。脂肪分布变化是根据其参数与随访时间之间的线性回归系数得出的:经过平均 6.2 年的随访,协方差分析(ANCOVA)和线性回归显示,血清 TMAO 水平越高的女性,其躯干 FLR(平均值±标准差:1.47±4.39,P-趋势 = 0.006)和 TLR(平均值±标准差:0.06±0.24,P-趋势 = 0.011)的增量越大。同时,线性混合效应模型(LMEM)分析表明,TMAO最高三分位数的女性躯干FLR和TLR的年估计增量(95% CI)分别为0.03(95% CI:0.003 - 0.06,P = 0.032)和1.28(95% CI:-0.17 - 2.73,P = 0.083)。在男性中,没有类似的显著观察结果。敏感性分析结果一致:结论:在目前的研究中,血清 TMAO 与中老年社区女性的 FLR 和 TLR 增量有更密切的相关性。结论:在本次研究中,血清 TMAO 与中老年社区居住妇女的 FLR 和 TLR 增量有更密切的相关性:NCT03179657.
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来源期刊
Nutrition Journal
Nutrition Journal NUTRITION & DIETETICS-
CiteScore
9.80
自引率
0.00%
发文量
68
审稿时长
4-8 weeks
期刊介绍: Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.
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