Characterization of Rhodiola heterodonta (Crassulaceae): Phytocomposition, Antioxidant and Antihyperglycemic Activities.

IF 1.6 Q3 FOOD SCIENCE & TECHNOLOGY
Zaripova Mr, Gayibova Sn, Makhmudov Rr, Mamadrahimov Aa, Vypova Nl, Gayibov Ug, Miralimova Sm, Aripov Tf
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引用次数: 0

Abstract

Plant extracts have been widely used in traditional medicine to prevent diabetes. The present study aimed to examine the antihyperglycemic properties of an ethanolic extract from Rhodiola heterodonta roots. In vitro evaluation revealed that treatment with the R. heterodonta extract resulted in significant reactive oxygen species inhibition, glucose binding, glucose transporter activation, and suppression of α-amylase and α-glucosidase. Moreover, the treatment with 100 mg/kg of R. heterodonta extract dramatically decreased glucose levels in glucose-, alloxan-, or adrenaline-induced diabetic rats. The information gathered in this study bridges the knowledge gap between traditional healers in Uzbekistan who utilize R. heterodonta and its potential for future medication development.

红景天(十字花科)的特征:植物成分、抗氧化和降血糖活性。
植物提取物在传统医学中被广泛用于预防糖尿病。本研究旨在研究红景天根部乙醇提取物的抗高血糖特性。体外评估显示,红景天提取物能显著抑制活性氧、葡萄糖结合、激活葡萄糖转运体、抑制α-淀粉酶和α-葡萄糖苷酶。此外,用 100 毫克/千克的异鸦胆子提取物处理葡萄糖、阿脲或肾上腺素诱导的糖尿病大鼠,可大大降低其血糖水平。本研究收集的信息弥补了乌兹别克斯坦传统治疗师对异烟肼的使用及其未来药物开发潜力之间的知识差距。
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来源期刊
Preventive Nutrition and Food Science
Preventive Nutrition and Food Science Agricultural and Biological Sciences-Food Science
CiteScore
3.40
自引率
0.00%
发文量
35
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