Isolation, Characterization, and Antiproliferative Activity of Terpenoids from the Tropical Plant Turraea delphinensis.

IF 3.3 2区生物学 Q2 CHEMISTRY, MEDICINAL

Journal of Natural Products Pub Date : 2024-07-26 Epub Date: 2024-07-06 DOI:10.1021/acs.jnatprod.4c00313

Hayato Kouno, Saidanxia Amuti, Yohei Saito, Shuichi Fukuyoshi, Katsunori Miyake, Masuo Goto, David J Newman, Barry R O'Keefe, Kuo-Hsiung Lee, Kyoko Nakagawa-Goto

引用次数: 0

Abstract

The isolation, structure determination, and biological evaluation of constituents from the organic extract of Turraea delphinensis Wahlert (Meliaceae) resulted in the isolation of 51 secondary metabolites, including 14 new terpenoids (six cycloartanes, four tirucallanes/euphanes, three limonoids, and a 7-keto sterol). Among the new compounds, 1 is the first triterpenoid with a trioxaspiro[4.4]nonane side chain, while 11-13 are the first 17-γ-lactone tetranortriterpenoids with four oxygenated functional groups at C-1, -3, -6, and -7. The isolated compounds were evaluated for antiproliferative activity against five human tumor cell lines, including a vinblastine-resistant cell line.

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热带植物 Turraea delphinensis 中萜类化合物的分离、特征和抗增殖活性。

通过对 Meliaceus Turraea delphinensis Wahlert（瓜菜科）有机提取物中成分的分离、结构测定和生物学评价，分离出 51 种次级代谢物，其中包括 14 种新的萜类化合物（6 种环木菠萝烷类、4 种 tirucallanes/euphanes 类、3 种柠檬醛类和 1 种 7-酮甾醇）。在这些新化合物中，1 是第一个具有三氧杂螺[4.4]壬烷侧链的三萜类化合物，而 11-13 则是第一个在 C-1、-3、-6 和 -7 处具有四个含氧官能团的 17-γ- 内酯四三萜类化合物。分离出的化合物对五种人类肿瘤细胞系进行了抗增殖活性评估，其中包括一种耐长春新碱的细胞系。

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来源期刊

Journal of Natural Products 生物-药学

CiteScore

9.10

自引率

5.90%

发文量

294

审稿时长

2.3 months

期刊介绍： The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin. When new compounds are reported, manuscripts describing their biological activity are much preferred. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.

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