Research progress in the treatment of an immune system disease-type 1 diabetes-by regulating the intestinal flora with Chinese medicine and food homologous drugs.

IF 2.5 Q3 MICROBIOLOGY
Bioscience of microbiota, food and health Pub Date : 2024-01-01 Epub Date: 2024-02-21 DOI:10.12938/bmfh.2023-068
Yang Ping, Jianing Liu, Huilin Wang, Yan Wang, Hongbin Qiu, Yu Zhang
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Abstract

Type 1 diabetes (T1D) is a specific autoimmune disease related to genetic and autoimmune factors. Recent studies have found that the intestinal flora is one of the important environmental factors in the development of T1D. The gut microbiota is the largest microbiota in the human body and has a significant impact on material and energy metabolism. Related studies have found that the intestinal floras of T1D patients are unbalanced. Compared with normal patients, the abundance of beneficial bacteria is reduced, and various pathogenic bacteria are significantly increased, affecting the occurrence and development of diabetes. Medicinal and food homologous traditional Chinese medicine (TCM) has a multicomponent, multitarget, and biphasic regulatory effect. Its chemical composition can increase the abundance of beneficial bacteria, improve the diversity of the intestinal flora, reduce blood sugar, and achieve the purpose of preventing and treating T1D by regulating the intestinal flora and its metabolites. Therefore, based on a review of T1D, intestinal flora, and TCM derived from medicine and food, this review describes the relationship between T1D and the intestinal flora, as well as the research progress of TCM interventions for T1D through regulation of the intestinal flora. Medicine and food homologous TCM has certain advantages in treating diabetes and regulating the intestinal flora. It can be seen that there is still great research space and broad development prospects for the treatment of diabetes by regulating the intestinal flora with drug and food homologous TCM.

用中药和食物同源药物调节肠道菌群治疗免疫系统疾病--1 型糖尿病的研究进展。
1 型糖尿病(T1D)是一种特殊的自身免疫性疾病,与遗传和自身免疫因素有关。最新研究发现,肠道菌群是 T1D 发病的重要环境因素之一。肠道微生物群是人体内最大的微生物群,对物质和能量代谢有重要影响。相关研究发现,T1D 患者的肠道菌群失调。与正常人相比,有益菌数量减少,各种致病菌明显增多,影响糖尿病的发生和发展。药食同源中药具有多成分、多靶点、双相调节作用。其化学成分可通过调节肠道菌群及其代谢产物,增加有益菌的丰度,改善肠道菌群的多样性,降低血糖,达到防治T1D的目的。因此,本综述在综述T1D、肠道菌群、药食同源中药的基础上,阐述了T1D与肠道菌群的关系,以及通过调节肠道菌群对T1D进行中医干预的研究进展。药食同源的中医药在治疗糖尿病和调节肠道菌群方面具有一定的优势。可见,药食同源中医药通过调节肠道菌群治疗糖尿病仍有很大的研究空间和广阔的发展前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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6.20
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