Associations between dietary iron intake from different sources and non-alcoholic fatty liver disease in adults.

IF 1.3 4区 医学 Q4 NUTRITION & DIETETICS
Chuanjing Chen, Jianhong Dong, Haihong Liu, Teng Ma, Yongye Sun
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引用次数: 0

Abstract

Background and objectives: Non-alcoholic fatty liver disease (NAFLD) has become a worldwide public health problem. Current evidence on the association between dietary iron intake and the risk of NAFLD is limited. The present study aimed to investigate the associations of animal-derived dietary iron (ADDI) intake, plant-derived dietary iron (PDDI) intake, and the ratio of PDDI:ADDI with NAFLD risk among U.S. adult population.

Methods and study design: This was a repeated cross-sectional study. Data were collected from the National Health and Nutrition Examination Survey (NHANES) 2007-2018. NAFLD was defined as a United States Fatty Lives Index ≥30, and dietary iron intake was assessed through two 24-h dietary recall in-terviews. Logistic regression and restricted cubic spline models were applied to examine the associations between dietary iron intake from different sources and NAFLD risk.

Results: A total of 9478 participants aged ≥20 years were enrolled in the present study. After adjustment for multiple confounding factors, relative to the lowest quartile, the odds ratio (OR) and 95% confidence interval (CI) of NAFLD for the highest quartile was 1.01(95% CI, 0.82-1.24) for ADDI intake, 0.82 (95% CI, 0.64-0.99) for PDDI intake, and 1.00 (95% CI, 0.81-1.24) for the PDDI: ADDI intake ratio. In stratified analysis by sex and age, the significantly negative associations of PDDI intake with NAFLD was observed in women and participants older than 45 years. Dose-response analyses indicated that NAFLD was negatively associated with PDDI intake in a non-linear manner.

Conclusions: PDDI intake was negatively associated with NAFLD in U.S. adults.

不同来源的膳食铁摄入量与成人非酒精性脂肪肝之间的关系。
背景和目的:非酒精性脂肪肝(NAFLD)已成为一个全球性的公共卫生问题。目前有关膳食铁摄入量与非酒精性脂肪肝风险之间关系的证据有限。本研究旨在调查美国成人非酒精性脂肪肝风险与动物源性膳食铁(ADDI)摄入量、植物源性膳食铁(PDDI)摄入量以及 PDDI:ADDI 比值之间的关系:这是一项重复性横断面研究。数据来自 2007-2018 年美国国家健康与营养调查(NHANES)。非酒精性脂肪肝的定义是美国脂肪肝指数≥30,膳食中铁的摄入量通过两次24小时膳食回忆访谈进行评估。采用逻辑回归和限制性立方样条模型来研究不同来源的膳食铁摄入量与非酒精性脂肪肝风险之间的关系:本研究共招募了 9478 名年龄≥20 岁的参与者。在对多种混杂因素进行调整后,相对于最低四分位数,最高四分位数非酒精性脂肪肝的几率比(OR)和 95% 置信区间(CI)分别为:ADDI 摄入量为 1.01(95% CI,0.82-1.24),PDDI 摄入量为 0.82(95% CI,0.64-0.99),PDDI:ADDI 摄入量比为 1.00(95% CI,0.81-1.24)。在按性别和年龄进行的分层分析中,女性和 45 岁以上的参与者的 PDDI 摄入量与非酒精性脂肪肝呈显著负相关。剂量-反应分析表明,非酒精性脂肪肝与 PDDI 摄入量呈非线性负相关:结论:在美国成年人中,PDDI 摄入量与非酒精性脂肪肝呈负相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.50
自引率
7.70%
发文量
58
审稿时长
6-12 weeks
期刊介绍: The aims of the Asia Pacific Journal of Clinical Nutrition (APJCN) are to publish high quality clinical nutrition relevant research findings which can build the capacity of clinical nutritionists in the region and enhance the practice of human nutrition and related disciplines for health promotion and disease prevention. APJCN will publish original research reports, reviews, short communications and case reports. News, book reviews and other items will also be included. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by at least two anonymous reviewers and the Editor. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as material cannot be returned. Final acceptance or rejection rests with the Editorial Board
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