Bromine/Sulfur-Substituted 9H-Carbazoles Produced by the Marine-Derived Streptomyces sp. OUCMDZ-5511 upon NaBr Exposure.

IF 3.3 2区生物学 Q2 CHEMISTRY, MEDICINAL

Journal of Natural Products Pub Date : 2024-07-26 Epub Date: 2024-07-01 DOI:10.1021/acs.jnatprod.4c00317

Pengcheng Yan, Jibin Liu, Kaixuan Li, Peipei Liu, Ning Li, Weiming Zhu

引用次数: 0

Abstract

Ten undocumented carbazole derivatives (2-11) along with the reported analogue (1) were isolated from the mangrove-derived Streptomyces sp. OUCMDZ-5511, cultured with NaBr-supplemented liquid medium. Compounds 1-7 are brominated carbazoles, and 8, 10, and 11 feature an additional thiazole or 2,3-dihydro-1,4-oxathiine rings, respectively. Their structures were identified through spectroscopic techniques, computational chemistry, and X-ray crystallography. Notably, compounds 6 and 8 effectively inhibited immune cell migration, indicating anti-inflammatory activity in vivo, potentially via Myd88/Nf-κB pathways, as suggested for compound 6.

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海洋链霉菌 OUCMDZ-5511 在 NaBr 暴露下产生的溴/硫代 9H-Carbazoles

从使用 NaBr 补充液体培养基培养的红树林链霉菌 OUCMDZ-5511 中分离出了十种未记载的咔唑衍生物（2-11）以及已报道的类似物（1）。化合物 1-7 是溴化咔唑，而 8、10 和 11 则分别具有额外的噻唑环或 2,3- 二氢-1,4-氧硫环。它们的结构是通过光谱技术、计算化学和 X 射线晶体学确定的。值得注意的是，化合物 6 和 8 能有效抑制免疫细胞的迁移，这表明它们在体内具有抗炎活性，可能是通过 Myd88/Nf-κB 途径，正如化合物 6 所表明的那样。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Natural Products 生物-药学

CiteScore

9.10

自引率

5.90%

发文量

294

审稿时长

2.3 months

期刊介绍： The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin. When new compounds are reported, manuscripts describing their biological activity are much preferred. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.