Meta-analysis of structural and functional abnormalities in behavioral addictions

IF 3.7 2区医学 Q1 PSYCHOLOGY, CLINICAL

Addictive behaviors Pub Date : 2024-06-15 DOI:10.1016/j.addbeh.2024.108088

Bohui Mei , Qiuying Tao , Jinghan Dang , Xiaoyu Niu , Jieping Sun , Mengzhe Zhang , Weijian Wang , Shaoqiang Han , Yong Zhang , Jingliang Cheng

{"title":"Meta-analysis of structural and functional abnormalities in behavioral addictions","authors":"Bohui Mei , Qiuying Tao , Jinghan Dang , Xiaoyu Niu , Jieping Sun , Mengzhe Zhang , Weijian Wang , Shaoqiang Han , Yong Zhang , Jingliang Cheng","doi":"10.1016/j.addbeh.2024.108088","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>The incidence of behavioral addictions (BAs) associated with scientific and technological advances has been increasing steadily. Unfortunately, a large number of studies on the structural and functional abnormalities have shown poor reproducibility, and it remains unclear whether different addictive behaviors share common underlying abnormalities. Therefore, our objective was to conduct a quantitative <em>meta</em>-analysis of different behavioral addictions to provide evidence-based evidence of common structural and functional changes.</p></div><div><h3>Methods:</h3><p>We conducted systematic searches in PubMed, Web of Science and Scopus from January 2010 to December 2023, supplementing reference lists of high-quality relevant <em>meta</em>-analyses and reviews, to identify eligible voxel-based morphometry (VBM) and functional magnetic resonance imaging (fMRI) studies. Using anisotropic seed-based D-Mapping (AES-SDM) <em>meta</em>-analysis methods, we compared brain abnormalities between BAs and healthy controls (HCs).</p></div><div><h3>Results</h3><p>There were 11 GMV studies (287 BAs and 292 HCs) and 26 fMRI studies (577 BAs and 545 HCs) that met inclusion criteria. Compared with HCs, BAs demonstrated significant reductions in gray matter volume (GMV) in (1) right anterior cingulate gyri extending into the adjacent superior frontal gyrus, as well as in the left inferior frontal gyrus and right striatum. (2) the bilateral precuneus, right supramarginal gyrus, and right fusiform gyrus were hyperfunction; (3) the left medial cingulate gyrus extended to the superior frontal gyrus, the left inferior frontal gyrus, and right middle temporal gyrus had hypofunction.</p></div><div><h3>Conclusions</h3><p>Our study identified structural and functional impairments in brain regions involved in executive control, cognitive function, visual memory, and reward-driven behavior in BAs. Notably, fronto-cingulate regions may serve as common biomarkers of BAs.</p></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"157 ","pages":"Article 108088"},"PeriodicalIF":3.7000,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Addictive behaviors","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0306460324001370","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHOLOGY, CLINICAL","Score":null,"Total":0}

引用次数: 0

Abstract

Background

The incidence of behavioral addictions (BAs) associated with scientific and technological advances has been increasing steadily. Unfortunately, a large number of studies on the structural and functional abnormalities have shown poor reproducibility, and it remains unclear whether different addictive behaviors share common underlying abnormalities. Therefore, our objective was to conduct a quantitative meta-analysis of different behavioral addictions to provide evidence-based evidence of common structural and functional changes.

Methods:

We conducted systematic searches in PubMed, Web of Science and Scopus from January 2010 to December 2023, supplementing reference lists of high-quality relevant meta-analyses and reviews, to identify eligible voxel-based morphometry (VBM) and functional magnetic resonance imaging (fMRI) studies. Using anisotropic seed-based D-Mapping (AES-SDM) meta-analysis methods, we compared brain abnormalities between BAs and healthy controls (HCs).

Results

There were 11 GMV studies (287 BAs and 292 HCs) and 26 fMRI studies (577 BAs and 545 HCs) that met inclusion criteria. Compared with HCs, BAs demonstrated significant reductions in gray matter volume (GMV) in (1) right anterior cingulate gyri extending into the adjacent superior frontal gyrus, as well as in the left inferior frontal gyrus and right striatum. (2) the bilateral precuneus, right supramarginal gyrus, and right fusiform gyrus were hyperfunction; (3) the left medial cingulate gyrus extended to the superior frontal gyrus, the left inferior frontal gyrus, and right middle temporal gyrus had hypofunction.

Conclusions

Our study identified structural and functional impairments in brain regions involved in executive control, cognitive function, visual memory, and reward-driven behavior in BAs. Notably, fronto-cingulate regions may serve as common biomarkers of BAs.

查看原文本刊更多论文

行为成瘾的结构和功能异常元分析。

背景：与科技进步相关的行为成瘾（BA）发病率一直在稳步上升。遗憾的是，大量关于结构和功能异常的研究显示其重复性较差，而且不同成瘾行为是否具有共同的潜在异常仍不清楚。因此，我们的目标是对不同行为成瘾进行定量荟萃分析，为共同的结构和功能变化提供循证证据：我们在 2010 年 1 月至 2023 年 12 月期间对 PubMed、Web of Science 和 Scopus 进行了系统检索，并补充了高质量相关荟萃分析和综述的参考文献列表，以确定符合条件的体素形态计量学（VBM）和功能磁共振成像（fMRI）研究。利用基于各向异性种子的D-映射（AES-SDM）荟萃分析方法，我们比较了BA和健康对照组（HC）的大脑异常情况：有 11 项 GMV 研究（287 名 BA 和 292 名 HC）和 26 项 fMRI 研究（577 名 BA 和 545 名 HC）符合纳入标准。与 HCs 相比，BAs 在以下部位的灰质体积（GMV）显著减少：(1) 右侧扣带回前部延伸至邻近的额上回，以及左侧额下回和右侧纹状体。(2)双侧楔前回、右侧徽上回和右侧纺锤回功能亢进；(3)左侧扣带回内侧延伸至额上回、左侧额下回和右侧颞中回功能低下：结论：我们的研究发现了 BAs 大脑区域的结构和功能障碍，这些区域涉及执行控制、认知功能、视觉记忆和奖赏驱动行为。值得注意的是，前扣带回区域可能是 BAs 的常见生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Addictive behaviors 医学-药物滥用

CiteScore

8.40

自引率

4.50%

发文量

283

审稿时长

46 days

期刊介绍： Addictive Behaviors is an international peer-reviewed journal publishing high quality human research on addictive behaviors and disorders since 1975. The journal accepts submissions of full-length papers and short communications on substance-related addictions such as the abuse of alcohol, drugs and nicotine, and behavioral addictions involving gambling and technology. We primarily publish behavioral and psychosocial research but our articles span the fields of psychology, sociology, psychiatry, epidemiology, social policy, medicine, pharmacology and neuroscience. While theoretical orientations are diverse, the emphasis of the journal is primarily empirical. That is, sound experimental design combined with valid, reliable assessment and evaluation procedures are a requisite for acceptance. However, innovative and empirically oriented case studies that might encourage new lines of inquiry are accepted as well. Studies that clearly contribute to current knowledge of etiology, prevention, social policy or treatment are given priority. Scholarly commentaries on topical issues, systematic reviews, and mini reviews are encouraged. We especially welcome multimedia papers that incorporate video or audio components to better display methodology or findings. Studies can also be submitted to Addictive Behaviors? companion title, the open access journal Addictive Behaviors Reports, which has a particular interest in ''non-traditional'', innovative and empirically-oriented research such as negative/null data papers, replication studies, case reports on novel treatments, and cross-cultural research.