Probiotic-Reduced Inflammaging in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.

IF 4.4 2区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Probiotics and Antimicrobial Proteins Pub Date : 2025-10-01 Epub Date: 2024-06-19 DOI:10.1007/s12602-024-10310-7

Irini Lazou-Ahrén, Malin Björklund, Göran Molin, Jie Xu, Gunilla Önning, Sölve Elmståhl, Bengt Jeppsson

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Abstract

The disparity between increased lifespan and healthy aging, marked by prevalent "inflammaging", highlights the global challenge in care of older persons. This study explored the anti-inflammatory effects of Lactiplantibacillus plantarum HEAL9 (LpHEAL9), alone or combined with berries, on older volunteers with chronic low-grade inflammation (LGI). It was a randomized, double-blind, placebo-controlled trial, with a total of 66 volunteers (> 70 years old), randomly assigned, and equally distributed, to placebo, LpHEAL9 or LpHEAL9 + Berries group. After a 2-week run-in period, participants underwent a 4-week dietary intervention. Intake of LpHEAL9 showed a trend towards reduction in serum CRP but without reaching statistical significance. However, LpHEAL9 significantly decreased fecal calprotectin levels compared to placebo. LpHEAL9+Berries did not show any effect on inflammation. Both probiotic groups showed a trend in improving cognitive function albeit not reaching statistical significance. Our findings suggest that the probiotic strain L. plantarum HEAL9 has a modest impact on LGI in a healthy older population (ClinicalTrials.gov ID: NCT02342496).

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益生菌减轻老年人炎症反应：一项随机、双盲、安慰剂对照试验

以普遍 "炎症 "为特征的寿命延长与健康老龄化之间的差距凸显了老年人护理方面的全球性挑战。这项研究探讨了植物乳杆菌 HEAL9（LpHEAL9）单独或与浆果一起服用对患有慢性低度炎症（LGI）的老年志愿者的抗炎作用。这是一项随机、双盲、安慰剂对照试验，共有 66 名志愿者（70 岁以上）被随机平均分配到安慰剂组、LpHEAL9 组或 LpHEAL9 + 浆果组。经过 2 周的磨合期后，参与者接受为期 4 周的饮食干预。摄入 LpHEAL9 有降低血清 CRP 的趋势，但未达到统计学意义。不过，与安慰剂相比，LpHEAL9能显著降低粪便钙蛋白水平。LpHEAL9+浆果对炎症没有任何影响。两组益生菌均显示出改善认知功能的趋势，但未达到统计学意义。我们的研究结果表明，益生菌株植物乳杆菌 HEAL9 对健康老年人群的 LGI 有一定影响（ClinicalTrials.gov ID：NCT02342496）。

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来源期刊

Probiotics and Antimicrobial Proteins BIOTECHNOLOGY & APPLIED MICROBIOLOGYMICROB-MICROBIOLOGY

CiteScore

11.30

自引率

6.10%

发文量

140

期刊介绍： Probiotics and Antimicrobial Proteins publishes reviews, original articles, letters and short notes and technical/methodological communications aimed at advancing fundamental knowledge and exploration of the applications of probiotics, natural antimicrobial proteins and their derivatives in biomedical, agricultural, veterinary, food, and cosmetic products. The Journal welcomes fundamental research articles and reports on applications of these microorganisms and substances, and encourages structural studies and studies that correlate the structure and functional properties of antimicrobial proteins.