Antidiabetic and antioxidant activity of Clitoria ternatea flower extracts and fractions on blood glucose and MDA in rats induced by alloxan

IF 0.5 Q4 EDUCATION, SCIENTIFIC DISCIPLINES

Pharmacy Education Pub Date : 2024-06-14 DOI:10.46542/pe.2024.246.2127

Widyaningrum Utami, Yunanto Dwi Laksono, Syakira Nilam Farhana Setiawibowo, Endang Sri Sunarsih, Fitri Wulandari, Evieta Rohana

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Abstract

Background: Clitoria ternatea, rich in anthocyanins with antioxidant properties, can help prevent oxidative stress and reduce complications associated with diabetes mellitus (DM). Objective: To investigate the antidiabetic and antioxidant properties of the ethanol extract and ethyl acetate fraction of Clitoria ternatea in rats induced by Alloxan. Method: Ethanol extract from Clitoria ternatea was fractionated with ethyl acetate and then screened for phytochemicals using TLC. Antidiabetic and antioxidant activities were evaluated on alloxan-induced hyperglycemic rats at 150 mg/kgBW and 300 mg/kgBW, respectively. Result: The Clitoria ternatea flower's ethanol extract and ethyl acetate fraction had a flavonoid content of 68.003±0.366 mg QE/g and 78.767±0.262 mg QE/g, respectively. The ethyl acetate fraction, administered at 300 mg/kg BW, showed a 45.5986 mg/dl reduction in blood glucose levels, not significantly different from the positive control (acarbose (p = 0.14). The ethyl acetate fraction showed a significant reduction of 76.5% in MDA levels, similar to quercetin as a positive control (p = 0.275). Conclusion: Clitoria ternatea showed antidiabetic and antioxidant properties in alloxan-induced rats.

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燕麦花提取物和馏分对阿脲诱导的大鼠血糖和 MDA 的抗糖尿病和抗氧化活性

背景：三棱牡荆富含具有抗氧化特性的花青素，有助于防止氧化应激和减少糖尿病（DM）相关并发症：目的：研究在阿脲诱导的大鼠体内鞣花阴蒂乙醇提取物和乙酸乙酯馏分的抗糖尿病和抗氧化特性：方法：用乙酸乙酯萃取燕麦的乙醇提取物，然后用 TLC 筛选植物化学物质。分别以 150 毫克/千克体重和 300 毫克/千克体重的剂量对阿脲诱导的高血糖大鼠进行了抗糖尿病和抗氧化活性评估：结果：虎耳草花的乙醇提取物和乙酸乙酯馏分中的类黄酮含量分别为 68.003±0.366 mg QE/g 和 78.767±0.262 mg QE/g。按 300 毫克/千克体重的剂量给药乙酸乙酯馏分可降低血糖水平 45.5986 毫克/分升，与阳性对照阿卡波糖（p = 0.14）无显著差异。乙酸乙酯部分显示 MDA 水平显著降低 76.5%，与阳性对照槲皮素相似（p = 0.275）：结论：赤芍对阿脲诱导的大鼠具有抗糖尿病和抗氧化作用。

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来源期刊

Pharmacy Education EDUCATION, SCIENTIFIC DISCIPLINES-

CiteScore

0.80

自引率

20.00%

发文量

174

期刊介绍： Pharmacy Education journal provides a research, development and evaluation forum for communication between academic teachers, researchers and practitioners in professional and pharmacy education, with an emphasis on new and established teaching and learning methods, new curriculum and syllabus directions, educational outcomes, guidance on structuring courses and assessing achievement, and workforce development. It is a peer-reviewed online open access platform for the dissemination of new ideas in professional pharmacy education and workforce development. Pharmacy Education supports Open Access (OA): free, unrestricted online access to research outputs. Readers are able to access the Journal and individual published articles for free - there are no subscription fees or ''pay per view'' charges. Authors wishing to publish their work in Pharmacy Education do so without incurring any financial costs.