Assessment of treatment retention rates and predictors of retention on opioid agonist treatment among adolescents

IF 3 3区医学 Q2 SUBSTANCE ABUSE

Drug and alcohol review Pub Date : 2024-06-17 DOI:10.1111/dar.13890

Pooja Shakya, Jaswant Jangra, Ravindra Rao, Ashwani Kumar Mishra, Roshan Bhad

{"title":"Assessment of treatment retention rates and predictors of retention on opioid agonist treatment among adolescents","authors":"Pooja Shakya, Jaswant Jangra, Ravindra Rao, Ashwani Kumar Mishra, Roshan Bhad","doi":"10.1111/dar.13890","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Introduction</h3>\n \n <p>Opioid agonist treatment (OAT) is an effective treatment for opioid dependence syndrome in adults. However, studies on effectiveness of OAT in adolescents are limited; existing studies show varying retention rates. The present study aimed to assess OAT retention rates in adolescent patients with opioid dependence syndrome registered in a community drug treatment clinic in Delhi, India, and to analyse factors associated with retention at 1 year.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Retrospective cohort study. All adolescents (<i>n</i> = 130) aged 10–19 years, started on OAT from January 2020 to July 2022 were included. Baseline and follow-up data was extracted from online record system maintained at the clinic. OAT retention rates at different timepoints were assessed. Multivariable logistic regression was used to discern factors associated with one-year retention.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The participants' mean age was 16.9 (SD 1.4) years. Mean age of starting opioids was 14.9 (SD 2.2) years; 29.5% (<i>n</i> = 38) injected opioids. The 6-, 12-, 18- and 24-month retention rate on OAT was 64.4%, 45.6%, 38.7% and 29% respectively. The retention rates with buprenorphine and methadone were comparable. Multivariate logistic regression showed retention for less than 12 months to be significantly associated with younger age of starting heroin, involvement in illegal activities, absenteeism from school and substance use in family.</p>\n </section>\n \n <section>\n \n <h3> Discussion and Conclusions</h3>\n \n <p>The 12-month retention rates on OAT in adolescents is comparable to retention rates in adults. Various factors associated with early age of onset of opioid use are also associated with lower retention rates on OAT.</p>\n </section>\n </div>","PeriodicalId":11318,"journal":{"name":"Drug and alcohol review","volume":"43 7","pages":"1835-1844"},"PeriodicalIF":3.0000,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug and alcohol review","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/dar.13890","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"SUBSTANCE ABUSE","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction

Opioid agonist treatment (OAT) is an effective treatment for opioid dependence syndrome in adults. However, studies on effectiveness of OAT in adolescents are limited; existing studies show varying retention rates. The present study aimed to assess OAT retention rates in adolescent patients with opioid dependence syndrome registered in a community drug treatment clinic in Delhi, India, and to analyse factors associated with retention at 1 year.

Methods

Retrospective cohort study. All adolescents (n = 130) aged 10–19 years, started on OAT from January 2020 to July 2022 were included. Baseline and follow-up data was extracted from online record system maintained at the clinic. OAT retention rates at different timepoints were assessed. Multivariable logistic regression was used to discern factors associated with one-year retention.

Results

The participants' mean age was 16.9 (SD 1.4) years. Mean age of starting opioids was 14.9 (SD 2.2) years; 29.5% (n = 38) injected opioids. The 6-, 12-, 18- and 24-month retention rate on OAT was 64.4%, 45.6%, 38.7% and 29% respectively. The retention rates with buprenorphine and methadone were comparable. Multivariate logistic regression showed retention for less than 12 months to be significantly associated with younger age of starting heroin, involvement in illegal activities, absenteeism from school and substance use in family.

Discussion and Conclusions

The 12-month retention rates on OAT in adolescents is comparable to retention rates in adults. Various factors associated with early age of onset of opioid use are also associated with lower retention rates on OAT.

查看原文本刊更多论文

评估青少年阿片类激动剂治疗的保留率和保留率的预测因素。

导言：阿片激动剂治疗（OAT）是治疗成人阿片依赖综合征的有效方法。然而，有关 OAT 在青少年中疗效的研究却十分有限；现有研究显示，OAT 的保留率各不相同。本研究旨在评估在印度德里一家社区戒毒诊所登记的阿片类药物依赖综合征青少年患者的OAT保留率，并分析保留1年的相关因素：方法：回顾性队列研究。研究纳入了 2020 年 1 月至 2022 年 7 月期间开始接受 OAT 治疗的所有 10-19 岁青少年（n = 130）。基线和随访数据来自诊所的在线记录系统。评估了不同时间点的 OAT 保持率。采用多变量逻辑回归分析与一年保留率相关的因素：参与者的平均年龄为 16.9 岁（标准差为 1.4 岁）。开始使用阿片类药物的平均年龄为 14.9 岁（标准差 2.2 岁）；29.5%（n = 38）的人注射过阿片类药物。OAT的6个月、12个月、18个月和24个月保留率分别为64.4%、45.6%、38.7%和29%。丁丙诺啡和美沙酮的保留率相当。多变量逻辑回归结果表明，留用时间少于12个月与开始吸食海洛因的年龄较小、参与非法活动、旷课和家庭中使用药物等因素有明显关系：青少年在 12 个月内继续服用 OAT 的比率与成年人相当。与开始使用阿片类药物的年龄较早有关的各种因素也与OAT的保持率较低有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Drug and alcohol review SUBSTANCE ABUSE-

CiteScore

4.80

自引率

10.50%

发文量

151

期刊介绍： Drug and Alcohol Review is an international meeting ground for the views, expertise and experience of all those involved in studying alcohol, tobacco and drug problems. Contributors to the Journal examine and report on alcohol and drug use from a wide range of clinical, biomedical, epidemiological, psychological and sociological perspectives. Drug and Alcohol Review particularly encourages the submission of papers which have a harm reduction perspective. However, all philosophies will find a place in the Journal: the principal criterion for publication of papers is their quality.