Fish oil supplementation and risk of incident systemic lupus erythematosus: a large population-based prospective study.

IF 4.4 2区医学 Q1 NUTRITION & DIETETICS

Nutrition Journal Pub Date : 2024-06-12 DOI:10.1186/s12937-024-00965-x

Yancong Chen, Zhilan Li, Yinyan Gao, Boya Xu, Weiru Zhang, Irene X Y Wu

{"title":"Fish oil supplementation and risk of incident systemic lupus erythematosus: a large population-based prospective study.","authors":"Yancong Chen, Zhilan Li, Yinyan Gao, Boya Xu, Weiru Zhang, Irene X Y Wu","doi":"10.1186/s12937-024-00965-x","DOIUrl":null,"url":null,"abstract":"Background: Although fish oil has been considered to have an anti-inflammatory effect and has been proven to play a beneficial role in the incidence of numerous diseases, the association between fish oil supplementation and the risk of systemic lupus erythematosus (SLE) is still unknown. This study aimed at evaluating the correlation between fish oil use and incident SLE in a large population-based prospective cohort.Methods: 390,277 participants without SLE at baseline from the UK Biobank were enrolled. Fish oil use was ascertained through a touchscreen questionnaire at baseline. The incidence of SLE was identified by the International Classification of Diseases version 10 code in medical records or self-report. Cox proportional hazard models were employed to estimate the association between fish oil use and SLE risk.Results: Fish oil users accounted for 31.47% of participants. During a median follow-up duration of 11.57 years, 141 participants without fish oil use (4.56/100 000 person-years) and 68 participants with fish oil use (4.78/100 000 person-years) developed SLE. In four models with adjustments for different amounts of confounders, there was no significant difference in the risk of SLE between fish oil users and fish oil non-users (all p-values > 0.05). In subgroup analyses, we found that fish oil supplementation was associated with a lower risk of SLE among females with ultraviolet radiation ≥ 3 h/day (hazard ratio: 0.63, 95% confidence interval: 0.40-0.98), which turned insignificant after further adjustment for female-related factors and sun protection measures.Conclusions: No significant association between fish oil use and overall incident SLE was observed, except in females exposed to prolonged ultraviolet radiation. Subgroup analysis suggested that females exposed to prolonged ultraviolet radiation might benefit from fish oil supplementation in terms of preventing SLE, but it needs to be confirmed in further studies.","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":null,"pages":null},"PeriodicalIF":4.4000,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11167923/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12937-024-00965-x","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Although fish oil has been considered to have an anti-inflammatory effect and has been proven to play a beneficial role in the incidence of numerous diseases, the association between fish oil supplementation and the risk of systemic lupus erythematosus (SLE) is still unknown. This study aimed at evaluating the correlation between fish oil use and incident SLE in a large population-based prospective cohort.

Methods: 390,277 participants without SLE at baseline from the UK Biobank were enrolled. Fish oil use was ascertained through a touchscreen questionnaire at baseline. The incidence of SLE was identified by the International Classification of Diseases version 10 code in medical records or self-report. Cox proportional hazard models were employed to estimate the association between fish oil use and SLE risk.

Results: Fish oil users accounted for 31.47% of participants. During a median follow-up duration of 11.57 years, 141 participants without fish oil use (4.56/100 000 person-years) and 68 participants with fish oil use (4.78/100 000 person-years) developed SLE. In four models with adjustments for different amounts of confounders, there was no significant difference in the risk of SLE between fish oil users and fish oil non-users (all p-values > 0.05). In subgroup analyses, we found that fish oil supplementation was associated with a lower risk of SLE among females with ultraviolet radiation ≥ 3 h/day (hazard ratio: 0.63, 95% confidence interval: 0.40-0.98), which turned insignificant after further adjustment for female-related factors and sun protection measures.

Conclusions: No significant association between fish oil use and overall incident SLE was observed, except in females exposed to prolonged ultraviolet radiation. Subgroup analysis suggested that females exposed to prolonged ultraviolet radiation might benefit from fish oil supplementation in terms of preventing SLE, but it needs to be confirmed in further studies.

查看原文本刊更多论文

鱼油补充剂与系统性红斑狼疮发病风险：一项大型人群前瞻性研究。

背景：尽管鱼油被认为具有抗炎作用，并已被证实对多种疾病的发病率有益，但鱼油补充剂与系统性红斑狼疮（SLE）发病风险之间的关系仍然未知。这项研究的目的是在一个基于人群的大型前瞻性队列中评估鱼油的使用与系统性红斑狼疮发病之间的相关性。通过基线触摸屏问卷调查确定了鱼油的使用情况。系统性红斑狼疮的发病率是通过医疗记录中的国际疾病分类第 10 版代码或自我报告确定的。采用 Cox 比例危险模型来估计鱼油使用与系统性红斑狼疮风险之间的关系：结果：鱼油使用者占参与者的31.47%。在中位 11.57 年的随访期间，141 名未使用鱼油的参与者（4.56/100 000 人-年）和 68 名使用鱼油的参与者（4.78/100 000 人-年）患上了系统性红斑狼疮。在对不同数量的混杂因素进行调整的四个模型中，鱼油使用者和非鱼油使用者患系统性红斑狼疮的风险没有显著差异（所有 p 值均大于 0.05）。在亚组分析中，我们发现在紫外线辐射≥3小时/天的女性中，补充鱼油与较低的系统性红斑狼疮风险相关（危险比：0.63，95%置信区间：0.40-0.98），在进一步调整女性相关因素和防晒措施后，危险比变得不显著：结论：除长期暴露于紫外线辐射的女性外，没有观察到鱼油的使用与系统性红斑狼疮的总体发病率有明显关系。亚组分析表明，长期暴露于紫外线辐射下的女性可能会从补充鱼油中获益，从而预防系统性红斑狼疮，但这还需要进一步研究证实。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nutrition Journal NUTRITION & DIETETICS-

CiteScore

9.80

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.